{
  "abstract": "A novel endoscopic device, ForePass (Keyron), demonstrated superior metabolic effects compared with semaglutide in preclinical testing. 12 young Landrace pigs underwent ForePass implantation, semaglutide treatment or sham endoscopy with a 1-month follow-up period. ForePass limited weight gain to +4.3%, compared with +36% in semaglutide-treated pigs and +47% in controls, without affecting linear growth. Food intake decreased by 26% with ForePass versus 18.5% with semaglutide. The device induced a near-flat glycaemic response and markedly improved insulin sensitivity (SI=2.75±0.37 pM⁻¹·min⁻¹), while semaglutide and sham produced only modest effects. These findings support clinical testing of ForePass as a minimally invasive, reversible approach for metabolic modulation.",
  "authors": [
    {
      "affiliations": [
        "Università Cattolica del Sacro Cuore Facoltà di Medicina e Chirurgia, Rome, Lazio, Italy"
      ],
      "name": "Sara Russo"
    },
    {
      "affiliations": [
        "Bariatric Endoscopy, Orlando Health Central Hospital, Ocoee, Florida, USA"
      ],
      "name": "Manoel Galvao Neto"
    },
    {
      "affiliations": [
        "Università Cattolica del Sacro Cuore, Milan, Italy"
      ],
      "name": "Elena Previti"
    },
    {
      "affiliations": [
        "Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Lazio, Italy"
      ],
      "name": "Vincenzo Bove"
    },
    {
      "affiliations": [
        "Internal Medicine, Universita Cattolica del Sacro Cuore, London, Italy",
        "Diabetes, King’s College London School of Medical Education, London, London, UK"
      ],
      "name": "Geltrude Mingrone"
    },
    {
      "affiliations": [
        "Digestive Endoscopy Unit, Università Cattolica del Sacro Cuore Facoltà di Medicina e Chirurgia, Rome, Lazio, Italy"
      ],
      "name": "Ivo Boskoski"
    }
  ],
  "title": "Endoluminal device induces insulin sensitivity and greater weight control than semaglutide in pigs",
  "uid": "ccf1c3b2-8316-5c1f-ac58-15bc35a68dd6"
}