{
  "abstract": "Current guidelines do not recommend routine proton pump inhibitor (PPI) use after endoscopic variceal ligation (EVL) because of limited evidence. In this randomised controlled trial of 170 patients (66.5% with alcohol-related liver disease), PPI therapy (40 mg daily for 3 months) was compared with no PPI treatment. Recurrent bleeding at 2 weeks and 3 months was significantly more frequent in the no-PPI group in both intention-to-treat (ITT) and per-protocol (PP) analyses, with absolute differences of 10%–15%. All deaths in the no-PPI group were related to rebleeding. Post-EVL ulcer extent and pain were also significantly reduced with PPI therapy. These findings indicate that post-EVL PPI use reduces rebleeding risk and may also lower associated mortality.",
  "authors": [
    {
      "affiliations": [
        "Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"
      ],
      "name": "Abhishek Yadav"
    },
    {
      "affiliations": [
        "Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"
      ],
      "name": "Harshal Surendra Mandavdhare"
    },
    {
      "affiliations": [
        "Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"
      ],
      "name": "Vishal Sharma"
    },
    {
      "affiliations": [
        "Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India"
      ],
      "name": "Atul Saroch"
    },
    {
      "affiliations": [
        "Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"
      ],
      "name": "Jimil Shah"
    },
    {
      "affiliations": [
        "Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India"
      ],
      "name": "Nitin Jagtap"
    },
    {
      "affiliations": [
        "Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"
      ],
      "name": "Anupam Kumar Singh"
    },
    {
      "affiliations": [
        "Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"
      ],
      "name": "Jayanta Samanta"
    },
    {
      "affiliations": [
        "Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"
      ],
      "name": "Vaneet Jearth"
    },
    {
      "affiliations": [
        "Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"
      ],
      "name": "Usha Dutta"
    },
    {
      "affiliations": [
        "Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"
      ],
      "name": "Saroj Kant Sinha"
    }
  ],
  "title": "Proton pump inhibitors should be continued after endoscopic variceal ligation",
  "uid": "aae77aef-9169-5e72-99dc-69869e8d8399"
}