{
  "abstract": "Functional dyspepsia and gastroparesis are characterised by similar primary symptoms: nausea, vomiting, postprandial fullness, early satiety and upper abdominal discomfort. However, the population prevalence of the two conditions is very different. The global prevalence of functional dyspepsia (54 127 respondents from 26 countries) was 7.2% (range 2.2–12.3%).1 On the other hand, the standardised prevalence of gastroparesis in the UK (Clinical Practice Research Datalink database2) and in the USA (US national administrative health insurance claims database3) were, respectively, 13.8 (95% CI 12.6 to 15.1) and 267.7 (95% CI 264.8 to 270.7) cases per 100 000 persons, that is, 0.014–0.267%. This wide prevalence range may reflect different criteria for ‘gastroparesis’ in nationwide databases. Based on the Rochester Epidemiology Project (Olmsted County, Minnesota, USA), the age-adjusted prevalence of definite gastroparesis (delayed gastric emptying by standard scintigraphy and typical symptoms for>3 months) was 24.2 (95% CI 15.7 to 32.6) per 100 000.4 When including probable (typical symptoms and food retention on endoscopy or upper gastrointestinal study) and possible (typical symptoms alone or delayed gastric emptying by scintigraphy without gastrointestinal symptoms) gastroparesis, the overall prevalence was 50.5 (95% CI 38.1 to 62.8) per 100 000, or approximately 0.5%. Thus, the estimated population prevalence of functional dyspepsia is at least 15-fold higher than that of gastroparesis.",
  "authors": [
    {
      "affiliations": [
        "Division of Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA"
      ],
      "name": "Michael Camilleri"
    },
    {
      "affiliations": [
        "School of Medicine and Public Health, The University of Newcastle Australia, Newcastle, New South Wales, Australia"
      ],
      "name": "Nicholas J Talley"
    }
  ],
  "title": "Are functional dyspepsia and gastroparesis really ‘interchangeable’ diseases?",
  "uid": "16ec8f18-6f78-5e2f-86ce-6e86291d6962"
}