{
  "abstract": "The recent commentary by Manning et al highlights difficulties comparing results of gastrointestinal microbiome cohort studies.1 They demonstrate how methodological heterogeneity can substantially impact data integration. Given the high interindividual variability in the gut microbiome, findings often require replication in large cohorts to ensure relevance and validity. To address this, integration and cross-validation of findings across varied cohort studies is vital.",
  "authors": [
    {
      "affiliations": [
        "Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK"
      ],
      "name": "Gregory R Young"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK",
        "Department of Medicine, University of Cambridge, Cambridge, UK"
      ],
      "name": "Nurulamin Noor"
    },
    {
      "affiliations": [
        "Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK"
      ],
      "name": "Aryan Khirwadkar"
    },
    {
      "affiliations": [
        "Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK"
      ],
      "name": "Lauren C Beck"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"
      ],
      "name": "Mohmmed Tauseef Sharip"
    },
    {
      "affiliations": [
        "Nutritional Sciences, King’s College London, London, UK"
      ],
      "name": "Kevin Whelan"
    },
    {
      "affiliations": [
        "Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK",
        "University of Exeter, Exeter, UK"
      ],
      "name": "Nicholas A Kennedy"
    },
    {
      "affiliations": [
        "Nuffield Department of Medicine, University of Oxford, Oxford, UK",
        "Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK"
      ],
      "name": "Jack Satsangi"
    },
    {
      "affiliations": [
        "Division of Digestive Diseases, Department of Metabolism, Imperial College London, London, UK"
      ],
      "name": "Julian Marchesi"
    },
    {
      "affiliations": [
        "Kennedy Institute of Rheumatology, Oxford University, Oxford, UK"
      ],
      "name": "Luke Jostins-Dean"
    },
    {
      "affiliations": [
        "Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK"
      ],
      "name": "Christopher Stewart"
    },
    {
      "affiliations": [
        "Department of Medicine, University of Cambridge, Cambridge, UK",
        "Cambridge Institute for Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK"
      ],
      "name": "Paul A Lyons"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK",
        "Department of Medicine, University of Cambridge, Cambridge, UK"
      ],
      "name": "Miles Parkes"
    },
    {
      "affiliations": [
        "Translational and Clinical Research Institute, Newcastle University Faculty of Medical Sciences, Newcastle upon Tyne, UK",
        "Department of Gastroenterology, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK"
      ],
      "name": "Christopher Andrew Lamb"
    },
    {
      "affiliations": [],
      "name": "IBD-RESPONSE collaborators"
    }
  ],
  "title": "Gut microbiome comparability between DNA extraction kits",
  "uid": "8c2a09b6-5f07-5525-b0f2-757a102a1654"
}