{
  "abstract": "In a recent publication in Gut, Fu et al1 report links between microbiome ageing trajectories, which correlate with other biological ageing processes, and chronic comorbidities. It is well demonstrated that people living with HIV (PLHIV) have accelerated biological ageing,2 including twice the risk of having clonal haematopoiesis (CH), the expansion of clonal populations of stem cells driven by specific somatic mutations that increase with age and are associated with inflammation.3 Research in the general population has demonstrated an association between diet quality and CH4 and between CH and liver disease.5 HIV infection leads to a reduction in gut-associated lymphoid tissue (GALT),6 resulting in microbial translocation and associated systemic inflammation and liver fibrosis,7 making the associations between the gastrointestinal tract and CH seen in the general population of particular relevance for PLHIV.",
  "authors": [
    {
      "affiliations": [
        "Kirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia",
        "Clinical Research Unit, University of New South Wales Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Mark W Donoghoe"
    },
    {
      "affiliations": [
        "Kirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Hossain MS Sazzad"
    },
    {
      "affiliations": [
        "Kirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Win Min Han"
    },
    {
      "affiliations": [
        "Kirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia",
        "Holdsworth House Medical Practice, Sydney, New South Wales, Australia"
      ],
      "name": "Mark Bloch"
    },
    {
      "affiliations": [
        "East Sydney Doctors, Sydney, New South Wales, Australia"
      ],
      "name": "David A Baker"
    },
    {
      "affiliations": [
        "Prahran Market Clinic, Melbourne, Victoria, Australia",
        "Melbourne Medical School, University of Melbourne, Melbourne, Victoria, Australia"
      ],
      "name": "Beng Eu"
    },
    {
      "affiliations": [
        "Kirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Ellen Bowden-Reid"
    },
    {
      "affiliations": [
        "Albion Centre, South Eastern Sydney Local Health District, Sydney, New South Wales, Australia",
        "School of Population Health, University of New South Wales Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Don E Smith"
    },
    {
      "affiliations": [
        "Department of Infectious Diseases, School of Translational Medicine, The Alfred Hospital and Monash University, Melbourne, Victoria, Australia"
      ],
      "name": "Jennifer F Hoy"
    },
    {
      "affiliations": [
        "Department of Infectious Diseases, School of Translational Medicine, The Alfred Hospital and Monash University, Melbourne, Victoria, Australia",
        "Monash Infectious Diseases, Monash Health, Clayton, Victoria, Australia",
        "Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia"
      ],
      "name": "Ian John Woolley"
    },
    {
      "affiliations": [
        "Taylor Square Private Clinic, Darlinghurst, New South Wales, Australia"
      ],
      "name": "Robert Finlayson"
    },
    {
      "affiliations": [
        "Kirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia",
        "Department of Sexual Health Medicine, Sydney Local Health District, Sydney, New South Wales, Australia",
        "Discipline of Medicine, Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "David J Templeton"
    },
    {
      "affiliations": [
        "Kirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia",
        "St Vincent’s Hospital Sydney, Darlinghurst, New South Wales, Australia"
      ],
      "name": "Gail V Matthews"
    },
    {
      "affiliations": [
        "Positive Life NSW, Sydney, New South Wales, Australia"
      ],
      "name": "Jane Costello"
    },
    {
      "affiliations": [
        "Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia",
        "Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia",
        "Collaborative Centre for Genomic Cancer Medicine, University of Melbourne, Melbourne, Victoria, Australia"
      ],
      "name": "Mark A Dawson"
    },
    {
      "affiliations": [
        "Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia",
        "Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia",
        "Collaborative Centre for Genomic Cancer Medicine, University of Melbourne, Melbourne, Victoria, Australia"
      ],
      "name": "Sarah-Jane Dawson"
    },
    {
      "affiliations": [
        "Kirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia",
        "Clinical Hub for Interventional Research, Australian National University, Canberra, Australian Capital Territory, Australia"
      ],
      "name": "Mark N Polizzotto"
    },
    {
      "affiliations": [
        "Kirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Esinam Agbosu"
    },
    {
      "affiliations": [
        "Kirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia",
        "St Vincent’s Hospital Sydney, Darlinghurst, New South Wales, Australia"
      ],
      "name": "Anthony D Kelleher"
    },
    {
      "affiliations": [
        "Kirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Kathy Petoumenos"
    },
    {
      "affiliations": [
        "Kirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Chansavath Phetsouphanh"
    },
    {
      "affiliations": [
        "Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia",
        "Monash Haematology, Monash Health, Clayton, Victoria, Australia"
      ],
      "name": "Paul Yeh"
    },
    {
      "affiliations": [
        "Kirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Nila J Dharan"
    },
    {
      "affiliations": [],
      "name": "ARCHIVE Study Group"
    }
  ],
  "title": "Gut health is associated with clonal haematopoiesis in older adults with and without HIV: the ARCHIVE longitudinal cohort study",
  "uid": "3767b7d3-c4d4-5850-ac6e-11432acfa353"
}