{
  "abstract": "We read with great interest the commentary by Benson Massey, which raises concerns about the recent widespread use of glucagon-like peptide-1 (GLP-1) agonists.1 We offer an alternative perspective and suggest that these medications can also have positive effects on the GI system. Here, we present preclinical results that reposition these drugs for the treatment of colitis and colitis-associated cancer (CAC). Our results are consistent with a recent study showing the safety of GLP-1 agonists in patients with IBD.2",
  "authors": [
    {
      "affiliations": [
        "Medicine/Gastroenterology and Liver Disease, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"
      ],
      "name": "Bianca N Islam"
    },
    {
      "affiliations": [
        "Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"
      ],
      "name": "Adrian Nguyen- Gomez"
    },
    {
      "affiliations": [
        "Medicine/Gastroenterology and Liver Disease, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"
      ],
      "name": "Kristina Williams"
    },
    {
      "affiliations": [
        "Surgery, Case Western Reserve University, Cleveland, Ohio, USA"
      ],
      "name": "Kimberly Curry"
    },
    {
      "affiliations": [
        "Medicine/Gastroenterology and Liver Disease, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"
      ],
      "name": "Neha S Khandekar"
    },
    {
      "affiliations": [
        "Universita del Salento, Lecce, Apulia, Italy"
      ],
      "name": "Marcello Chieppa"
    },
    {
      "affiliations": [
        "Pathology, University of South Alabama, Mobile, Alabama, USA"
      ],
      "name": "Wei Xin"
    },
    {
      "affiliations": [
        "Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"
      ],
      "name": "Theresa T Pizarro"
    },
    {
      "affiliations": [
        "Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"
      ],
      "name": "Rui Wang"
    },
    {
      "affiliations": [
        "Medicine/Gastroenterology and Liver Disease, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"
      ],
      "name": "Fabio Cominelli"
    }
  ],
  "title": "Repositioning dual GLP-1/GIP receptor agonists for the treatment of colitis and colitis-associated tumourigenesis",
  "uid": "e0ac1c74-0ff4-5398-80ed-bfee09e5f66a"
}