{
  "abstract": "In Gut, a study by Osswald et al1 links diet and microbially generated bile acids (BA) to colorectal cancer (CRC), a leading cause of cancer-related mortality worldwide. Dietary habits are a predominant modifiable risk factor, where Western diets, characterised by high saturated fat, low fibre and highly refined carbohydrates, are associated with increased CRC incidence.2 A long-standing hypothesis posits that Western diet-induced alterations in gut microbiota and, consequently, BA metabolism, particularly increased hydrophobic secondary BAs in the distal intestine, promote colorectal carcinogenesis.3 However, despite a large body of correlative human data,4 definitive causal evidence linking gut microbiota-derived secondary BAs to CRC development has remained elusive. The study by Osswald et al provides a critical advance by integrating large-animal models, gnotobiotic studies and multiomics analyses to establish a direct causal role for deoxycholic acid (DCA) generating gut bacteria in CRC progression.1",
  "authors": [
    {
      "affiliations": [
        "Physiology and Pharmacology, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA"
      ],
      "name": "Matam Vijay-Kumar"
    },
    {
      "affiliations": [
        "Physiology and Pharmacology, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA"
      ],
      "name": "Beng San Yeoh"
    },
    {
      "affiliations": [
        "Department of Biology, Center for Inflammation, Immunity and Infection, Georgia State University, Atlanta, Georgia, USA"
      ],
      "name": "Andrew T Gewirtz"
    }
  ],
  "title": "Hydroxylation matters! Microbial bile acid metabolism and colorectal cancer",
  "uid": "0c397c05-5524-534a-96e9-c071e11d9ee6"
}