{
  "abstract": "Primary biliary cholangitis (PBC) is a rare chronic autoimmune cholangiopathy that mainly affects middle-aged women, characterised by progressive destruction of the small intrahepatic bile ducts, leading to cholestasis, persistent inflammation and, over time, fibrogenesis. 1 Ursodeoxycholic acid (UDCA) remains the first-line therapy and has significantly improved prognosis through its hepatoprotective and choleretic effects. However, approximately one-third of patients show an inadequate response, with an increased risk of fibrosis progression and cirrhosis, highlighting a substantial unmet therapeutic need.2",
  "authors": [
    {
      "affiliations": [
        "Medicine and Surgery, University of Milan-Bicocca, Monza, Italy",
        "Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Lombardy, Italy"
      ],
      "name": "Naths Grazia Sukubo"
    },
    {
      "affiliations": [
        "Medicine and Surgery, University of Milan-Bicocca, Monza, Italy",
        "Gastroenterology, IRCCS San Gerardo dei Tintori Foundation Hospital, Monza, Italy"
      ],
      "name": "Chiara Caime"
    },
    {
      "affiliations": [
        "Division of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Lombardy, Italy"
      ],
      "name": "Alessio Gerussi"
    },
    {
      "affiliations": [
        "Program for Autoimmune Liver Diseases, International Center for Digestive Diseases, Department of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy"
      ],
      "name": "Pietro Invernizzi"
    }
  ],
  "title": "Kupffer cell autophagy emerges as a central regulator of immune dysregulation in primary biliary cholangitis",
  "uid": "d99a8920-8764-5e8b-b355-12ae1021c6d0"
}