{
  "abstract": "The pathogenesis of chronic diarrhoeal diseases remains incompletely understood, so it is exciting when novel mechanistic insights emerge. In their recent Gut publication, Bannon et al 1 report a large elevation of the promotility enteroendocrine hormone insulin-like peptide 5 (INSL5) in the serum of patients with bile salt diarrhoea (BSD) and in a subset of patients with Irritable bowel syndrome with diarrhoea (IBS-D) without overt bile salt malabsorption, using a modified liquid chromatography-tandem mass spectrometry assay with increased sensitivity that they developed. This finding opens a new direction into how colonic hormones may regulate bowel function and contribute to diarrhoeal pathophysiology.",
  "authors": [
    {
      "affiliations": [
        "Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"
      ],
      "name": "Mark Donowitz"
    },
    {
      "affiliations": [
        "Gastroenterology and Physiology, Johns Hopkins Medicine, Baltimore, Maryland, USA"
      ],
      "name": "Varsha Singh"
    }
  ],
  "title": "INSL5 as a newly recognised potential contributor to diarrhoea pathogenesis: more questions than answers",
  "uid": "543aecfb-9f4b-52c1-82ec-db87ac5324ed"
}