{
  "abstract": "Organ preservation has emerged as a therapeutic objective in low rectal cancer management, particularly for patients achieving complete or near-complete response following neoadjuvant chemoradiotherapy. While radical surgery remains the standard recommendation in current guidelines, watch-and-wait (WW) strategies are increasingly used. We report 28 cases managed with endoscopic full-thickness resection of the scar and adjacent tissue as an alternative, all with R0 resection. Histology showed ypT0, ypT1 and ypT2 in 17, 5 and 6 cases. Among ypT2 cases, one received salvage surgery, while five received adjuvant radiochemotherapy. All patients remained recurrence-free over a median 25-month follow-up. Major low anterior resection syndrome occurred in one patient.",
  "authors": [
    {
      "affiliations": [
        "Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Fudan University, Shanghai, Shanghai, China"
      ],
      "name": "Zhipeng Qi"
    },
    {
      "affiliations": [
        "Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Fudan University, Shanghai, Shanghai, China"
      ],
      "name": "Mingyan Cai"
    },
    {
      "affiliations": [
        "Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Fudan University, Shanghai, Shanghai, China"
      ],
      "name": "Ayimukedisi Yalikong"
    },
    {
      "affiliations": [
        "Department of Pathology, Zhongshan Hospital Fudan University, Shanghai, Shanghai, China"
      ],
      "name": "Haixing Wang"
    },
    {
      "affiliations": [
        "Department of Radiotherapy, Zhongshan Hospital Fudan University, Shanghai, Shanghai, China"
      ],
      "name": "Xian Zhang"
    },
    {
      "affiliations": [
        "Department of Colorectal Surgery, Zhongshan Hospital, Fudan University, Shanghai, China"
      ],
      "name": "De-xiang Zhu"
    },
    {
      "affiliations": [
        "Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Fudan University, Shanghai, Shanghai, China"
      ],
      "name": "Yunshi Zhong"
    }
  ],
  "title": "Refining watch-and-wait in low rectal cancer after neoadjuvant chemoradiotherapy: pilot study of endoscopic full-thickness resection",
  "uid": "9fae4e87-2d29-54c4-9826-6c385add2c45"
}