{
  "abstract": "We read with interest the article by Santacroce about personalised medicine in eosinophilic oesophagitis (EoE) and the identification of novel therapeutic targets.1 While dietary approaches are first-line treatment options for EoE, pathomechanisms are not well understood.2 Studies have shown that milk is the leading culprit category.3 4 It remains elusive if changes in dairy production are associated with EoE development. A dominant point mutation in beta casein occurred in ancestors to modern type cattle with a change from A2 milk (non-mutated) to A1/A2 milk (at least one point mutation, proline to histidine at position 67).5 Nothing is known about the allergenicity of standard versus A2 milk and its implications in EoE pathogenesis.",
  "authors": [
    {
      "affiliations": [
        "Department of Gastroenterology and Hepatology, University Hospital Zurich, Zürich, Switzerland"
      ],
      "name": "Alex Straumann"
    },
    {
      "affiliations": [
        "Department of Gastroenterology and Hepatology, University Hospital Zurich, Zürich, Switzerland"
      ],
      "name": "Emilie Gueguen"
    },
    {
      "affiliations": [
        "Department of Gastroenterology and Hepatology, University Hospital Zurich, Zürich, Switzerland"
      ],
      "name": "Andrea Kreienbühl"
    },
    {
      "affiliations": [
        "Division of Gastroenterology and Hepatology, Kantonsspital St Gallen, St. Gallen, Switzerland"
      ],
      "name": "Anne Godat"
    },
    {
      "affiliations": [
        "Division of Gastroenterology and Hepatology, Kantonsspital St Gallen, St. Gallen, Switzerland"
      ],
      "name": "Annett Franke"
    },
    {
      "affiliations": [
        "Nestlé Research, Société des Produits Nestlé S.A, Lausanne, Switzerland"
      ],
      "name": "Christophe Fuerer"
    },
    {
      "affiliations": [
        "Nestlé Research, Société des Produits Nestlé S.A, Lausanne, Switzerland"
      ],
      "name": "Mario Noti"
    },
    {
      "affiliations": [
        "Division of Pharmacology, Utrecht Insitute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands"
      ],
      "name": "Mirelle T A Kleuskens"
    },
    {
      "affiliations": [
        "Center of Gastroenterology Zurich, Zurich, Switzerland"
      ],
      "name": "Teresa Stelzer"
    },
    {
      "affiliations": [
        "Department of Gastroenterology and Hepatology, Amsterdam UMC, location AMC, Amsterdam, Netherlands"
      ],
      "name": "Albert J Bredenoord"
    },
    {
      "affiliations": [
        "Pathologie Langgasse, Bern, Switzerland"
      ],
      "name": "Biral Ruggero"
    },
    {
      "affiliations": [
        "Alys Pharmaceuticals, Aldena Therapeutics, London, UK"
      ],
      "name": "Carine Blanchard"
    },
    {
      "affiliations": [
        "Department of Gastroenterology and Hepatology, University Hospital Zurich, Zürich, Switzerland"
      ],
      "name": "Luc Biedermann"
    },
    {
      "affiliations": [
        "Department of Gastroenterology and Hepatology, University Hospital Lausanne - CHUV, Lausanne, Switzerland"
      ],
      "name": "Alain Schoepfer"
    },
    {
      "affiliations": [
        "Department of Gastroenterology and Hepatology, University Hospital Zurich, Zürich, Switzerland",
        "Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland",
        "Division of Gastroenterology and Hepatology, EOC, Lugano, Switzerland",
        "Institute of translational research, EOC, Bellinzona, Switzerland"
      ],
      "name": "Marcin Wawrzyniak"
    },
    {
      "affiliations": [
        "Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland",
        "Division of Gastroenterology and Hepatology, EOC, Lugano, Switzerland",
        "Institute of translational research, EOC, Bellinzona, Switzerland"
      ],
      "name": "Thomas Greuter"
    }
  ],
  "title": "Role of A2 beta casein in milk-induced eosinophilic oesophagitis: novel in-vivo and in-vitro findings",
  "uid": "22131203-6ebd-5fcf-90e8-2af60be443d2"
}