{
  "abstract": "A recent randomised controlled trial showed that proton pump inhibitors (PPIs), compared with histamine-2 receptor antagonists (H2RAs), induce greater gut microbiome alterations and oral-to-gut transmission, mechanisms that have been implicated in various gastrointestinal disorders, including inflammatory bowel disease (IBD).1 Although studies evaluating the association between PPIs and IBD have been conducted in adults,2 paediatric evidence remains scarce. Given the increasing global burden of IBD—particularly among children, who experience more aggressive disease and greater clinical impact3 4—together with rising PPI use in children and their vulnerability to drug toxicity,5 6 we investigated the risk of IBD associated with PPIs versus H2RAs in the paediatric population.",
  "authors": [
    {
      "affiliations": [
        "College of pharmacy, Chonnam National University, Buk-gu, Gwangju, Korea (the Republic of)"
      ],
      "name": "Yunha Noh"
    },
    {
      "affiliations": [
        "School of Pharmacy, Sungkyunkwan University, Suwon, Korea (the Republic of)"
      ],
      "name": "Ahhyung Choi"
    },
    {
      "affiliations": [
        "Department of Medical Informatics, Kangwon National University College of Medicine, Chuncheon-si, Korea (the Republic of)"
      ],
      "name": "Hyesung Lee"
    },
    {
      "affiliations": [
        "Department of Pediatrics, Kyung Hee University Medical Center, Seoul, Korea (the Republic of)"
      ],
      "name": "Dong Keon Yon"
    },
    {
      "affiliations": [
        "Yonsei University Wonju College of Medicine, Wonju, Korea (the Republic of)"
      ],
      "name": "Hyun-Soo Kim"
    },
    {
      "affiliations": [
        "School of Pharmacy, Sungkyunkwan University, Suwon, Korea (the Republic of)"
      ],
      "name": "Suyeon Kim"
    },
    {
      "affiliations": [
        "School of Pharmacy, Sungkyunkwan University, Suwon, Korea (the Republic of)",
        "Department of Biohealth Regulatory Science, Sungkyunkwan University, Suwon, Korea (the Republic of)"
      ],
      "name": "Ju-Young Shin"
    },
    {
      "affiliations": [
        "Department of Epidemiology, Biostatistics and Occupational Health",
        "Gerald Bronfman Department of Oncology, McGill University, Montreal, Quebec, Canada",
        "Center for Clinical Epidemiology, Lady Davis Institute, Montreal, Quebec, Canada"
      ],
      "name": "Laurent Azoulay"
    }
  ],
  "title": "Proton pump inhibitors use and risk of inflammatory bowel disease in children",
  "uid": "c3a11b85-2ae3-5fae-971b-b426f7be5ef4"
}