{
  "abstract": "We read with great interest the article of Ratziu and colleagues, who evaluated the potential of thrombospondin-2 (TSP2), insulin-like growth factor binding protein 7, CD163 and growth differentiation factor 15 (GDF15) as non-invasive biomarkers for identifying at-risk metabolic dysfunction associated steatohepatitis (MASH) and advanced liver fibrosis in a large multicentre European cohort.1 Plasma levels of these proteins were measured in patients with biopsy-proven MASH, and the authors tested the diagnostic performance for at-risk MASH and advanced fibrosis using area under the curve analysis. TSP2 had an AUROC of 0.812 for both advanced fibrosis and at-risk MASH, GDF15 had an AUROC of 0.738 and 732 for at-risk MASH and fibrosis, outperforming traditional screening measures such as FIB4 and VCTE. There remains a substantial unmet need for non-invasive biomarkers that can replace the invasive liver biopsy for the diagnosis of these conditions and this study clearly fills this gap.",
  "authors": [
    {
      "affiliations": [
        "Internal and vascular medicine, Amsterdam UMC Locatie AMC, Amsterdam, Netherlands"
      ],
      "name": "Mijra Koning"
    },
    {
      "affiliations": [
        "Amsterdam UMC Location AMC Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands",
        "Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, Netherlands"
      ],
      "name": "Isabelle van Thiel"
    },
    {
      "affiliations": [
        "Tytgat Institute for GI Research, Amsterdam UMC Locatie AMC, Amsterdam, Nh, Netherlands",
        "Dept of surgery, University of Bonn, Bonn, Germany"
      ],
      "name": "Wouter J de Jonge"
    },
    {
      "affiliations": [
        "Pathology, Amsterdam University Medical Centres, Amsterdam, Noord-Holland, Netherlands",
        "Pathology, Antwerp University Hospital, Antwerp, Belgium"
      ],
      "name": "Joanne Verheij"
    },
    {
      "affiliations": [
        "Spaarne Gasthuis, Haarlem, Noord-Holland, Netherlands"
      ],
      "name": "Sjoerd Bruin"
    },
    {
      "affiliations": [
        "Vascular Medicine, Amsterdam University Medical Centres, Amsterdam, Noord-Holland, Netherlands",
        "Diabeter, Diabeter Cenetrum Amsterdam, Amsterdam, Netherlands"
      ],
      "name": "Max Nieuwdorp"
    },
    {
      "affiliations": [
        "Amsterdam UMC Location AMC Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands",
        "Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, Netherlands"
      ],
      "name": "Abraham Meijnikman"
    }
  ],
  "title": "Potential of GDF15 goes beyond its role as a non-invasive biomarker for MASLD",
  "uid": "b5ef3be7-3d04-5247-9e52-21f4d64721ea"
}