{
  "abstract": "Background Cancers of the oesophagus and stomach are a major cause of morbidity and mortality. Research is crucial to improving outcomes. However, to maximise value and impact, areas of focus should be prioritised in partnership with patients.Objective We undertook a comprehensive analysis of UK and Ireland patient and healthcare professional (HCP) priorities for research into oesophagogastric cancers across the domains of prevention, diagnosis and staging, treatment, palliative care and survivorship.Design A scoping exercise sourced research questions from patients and HCPs. These were consolidated and then confirmed by systematic review to represent a true research uncertainty. Research questions were scored on potential impact by an interdisciplinary group of HCPs and prioritised using a weighting derived from a patient survey.Results There were 835 (395 HCP, 440 patient) respondents to the scoping (n=455) and prioritisation (n=380) surveys. Across these, 4295 suggested research uncertainties were consolidated to 92 uncertainties that were prioritised. HCP respondents represented 25 professional groups from community and hospital settings. Patient weighting changed 22.2–46.3% of priority rankings established by HCPs. All domains were represented by the 20 highest priority questions, 5 of which focused on personalising and optimally combining treatment modalities. Two other key themes related to optimising nutrition and improving quality of life during and after treatment, including in patients not cured of their cancer.Conclusion This work highlights the impact of patient input on HCP-ranked research priorities and provides a robust list of priorities to guide funders, policymakers and researchers to support and undertake impactful research.",
  "authors": [
    {
      "affiliations": [
        "Department of Oncology, University of Cambridge, Cambridge, UK",
        "Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"
      ],
      "name": "Christopher M Jones"
    },
    {
      "affiliations": [
        "Department of Oncology, University of Cambridge, Cambridge, UK",
        "Department of Public Health & Primary Care, University of Cambridge, Cambridge, UK"
      ],
      "name": "Wee Han Ng"
    },
    {
      "affiliations": [
        "Imperial College Healthcare NHS Trust, London, UK"
      ],
      "name": "Laura Tincknell"
    },
    {
      "affiliations": [
        "Department of Oncology, University of Cambridge, Cambridge, UK"
      ],
      "name": "Dylan P McClurg"
    },
    {
      "affiliations": [
        "Marie Curie Hospice, West Midlands, UK"
      ],
      "name": "Emily Adam"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Portsmouth University Hospitals NHS Trust, Portsmouth, UK"
      ],
      "name": "Pradeep Bhandari"
    },
    {
      "affiliations": [
        "School of Health & Social Care, Edinburgh Napier University, Edinburgh, UK"
      ],
      "name": "Karen Campbell"
    },
    {
      "affiliations": [
        "Cancer Services, University College London Hospitals NHS Foundation Trust, London, UK"
      ],
      "name": "Pinkie Chambers"
    },
    {
      "affiliations": [
        "Cancer Systems Biology Laboratory, The Francis Crick Institute, London, UK",
        "Centre for Cancer Evolution, Barts Cancer Institute, Queen Mary University of London, London, UK"
      ],
      "name": "Francesca Ciccarelli"
    },
    {
      "affiliations": [
        "Centre for Public Health, Queen's University Belfast, Belfast, UK"
      ],
      "name": "Helen G Coleman"
    },
    {
      "affiliations": [
        "Velindre Cancer Centre, Velindre University NHS Trust, Cardiff, UK"
      ],
      "name": "Tom Crosby"
    },
    {
      "affiliations": [
        "Oesophageal Cancer Fund, Dublin, Ireland"
      ],
      "name": "Carmel Doyle"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Guy’s and St Thomas’ NHS Foundation Trust, London, UK",
        "School of Cancer & Pharmaceutical Sciences, King’s College London, London, UK"
      ],
      "name": "Jason M Dunn"
    },
    {
      "affiliations": [
        "Trinity St James’s Cancer Institute, Trinity College Dublin and St James’s Hospital, Dublin, Ireland"
      ],
      "name": "Jessie Elliott"
    },
    {
      "affiliations": [
        "Department of Oncology, University of Cambridge, Cambridge, UK"
      ],
      "name": "Rebecca C Fitzgerald"
    },
    {
      "affiliations": [
        "Clinical Radiology, Velindre Cancer Centre, Velindre University NHS Trust, Cardiff, UK",
        "Division of Cancer & Genetics, School of Medicine, Cardiff University, Cardiff, UK"
      ],
      "name": "Kieran G Foley"
    },
    {
      "affiliations": [
        "School of Biomedical Engineering & Imaging Sciences, King’s College London, London, UK",
        "Department of Radiology, Guy's and St Thomas’ Hospitals NHS Trust, London, UK"
      ],
      "name": "Vicky Goh"
    },
    {
      "affiliations": [
        "Pathology and Data Analytics, Leeds Institute of Medical Research at St James’s, Faculty of Medicine & Health, University of Leeds, Leeds, UK",
        "Department of Pathology, GROW Research Institute for Oncology and Reproduction, Maastricht University Medical Centre, Maastricht, The Netherlands"
      ],
      "name": "Heike I Grabsch"
    },
    {
      "affiliations": [
        "Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK"
      ],
      "name": "Trevor A Graham"
    },
    {
      "affiliations": [
        "NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust/University of Southampton, Southampton, UK"
      ],
      "name": "Mike Grocott"
    },
    {
      "affiliations": [
        "South West Wales Cancer Centre, Swansea Bay University Health Board, Swansea, UK"
      ],
      "name": "Sarah Gwynne"
    },
    {
      "affiliations": [
        "Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK"
      ],
      "name": "Jo Harvey"
    },
    {
      "affiliations": [
        "Research Department of Pathology, UCL Cancer Institute, University College London, London, UK"
      ],
      "name": "Marnix Jansen"
    },
    {
      "affiliations": [
        "Department of Surgery and Cancer, Imperial College London, London, UK",
        "Department of Molecular Medicine & Surgery, Karolinska Instituet, Stockholm, Sweden"
      ],
      "name": "Pernilla Lagergren"
    },
    {
      "affiliations": [
        "Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"
      ],
      "name": "Claire Lamb"
    },
    {
      "affiliations": [
        "Therapies Department, The Royal Marsden NHS Foundation Trust, London, UK"
      ],
      "name": "Lauren Leigh-Doyle"
    },
    {
      "affiliations": [
        "East Sussex Healthcare NHS Trust, Eastbourne, UK",
        "St Wilfrid’s Hospice, Eastbourne, UK"
      ],
      "name": "Farida Malik"
    },
    {
      "affiliations": [
        "School of Medicine & Population Health, University of Sheffield, Sheffield, UK"
      ],
      "name": "Catriona Mayland"
    },
    {
      "affiliations": [
        "Heartburn Cancer UK, Hampshire, UK"
      ],
      "name": "Mimi McCord"
    },
    {
      "affiliations": [
        "Action Against Heartburn, London, UK"
      ],
      "name": "Alan Moss"
    },
    {
      "affiliations": [
        "Oxford Cancer & Haematology Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"
      ],
      "name": "Somnath Mukherjee"
    },
    {
      "affiliations": [
        "School of Medicine, University of Dundee, Dundee, UK",
        "Tayside Cancer Centre, Ninewells Hospital, Dundee, UK"
      ],
      "name": "Russell Petty"
    },
    {
      "affiliations": [
        "Aberdeen, Aberdeenshire, UK"
      ],
      "name": "Siddharth Rananaware"
    },
    {
      "affiliations": [
        "School of Nursing & Midwifery, Queen’s University Belfast, Belfast, UK"
      ],
      "name": "Joanne Reid"
    },
    {
      "affiliations": [
        "Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK"
      ],
      "name": "Gregory Rubin"
    },
    {
      "affiliations": [
        "Oxford Cancer & Haematology Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"
      ],
      "name": "Elizabeth Smyth"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Sandwell General Hospital, West Bromwich, UK",
        "Department of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK"
      ],
      "name": "Nigel J Trudgill"
    },
    {
      "affiliations": [
        "Centre for Public Health, Queen's University Belfast, Belfast, UK"
      ],
      "name": "Richard C Turkington"
    },
    {
      "affiliations": [
        "School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK"
      ],
      "name": "Timothy J Underwood"
    },
    {
      "affiliations": [
        "Wolfson Institute of Population Health, Queen Mary University of London, London, UK"
      ],
      "name": "Fiona M Walter"
    },
    {
      "affiliations": [
        "Therapies Department, Royal Surrey NHS Foundation Trust, Guildford, UK"
      ],
      "name": "Jessica Williams"
    },
    {
      "affiliations": [
        "Department of Surgery and Cancer, Imperial College London, London, UK"
      ],
      "name": "Christopher J Peters"
    }
  ],
  "title": "Research priorities for cancers of the oesophagus and stomach: recommendations from a UK and Ireland patient and healthcare professional partnership exercise",
  "uid": "4446f844-8c8e-5200-9b97-95f24d6317fc"
}