{
  "abstract": "Underwater endoscopic resections have emerged as promising alternatives to the conventional techniques for the treatment of large (≥2 cm) non-pedunculated colorectal polyps; this may also apply to colorectal endoscopic submucosal dissection (ESD) using saline. This retrospective study uses a propensity score-matched analysis of 82/208 such lesions treated during a 3-year period. Underwater ESD using saline improved R0 resection rates (97.6% vs 82.9%), enhanced dissection speed (31.8 mm 2/min vs 22.9 mm2/min) and reduced the use of haemostatic forceps for intraprocedural bleeding (0% vs 14.6%). We recommend this technique to be adopted to facilitate ESD for large non-pedunculated colorectal lesions.",
  "authors": [
    {
      "affiliations": [
        "Endoscopy Unit, Gastroenterology Department, IRCCS Humanitas Research Hospital, Rozzano, Italy",
        "IBD Unit, Department of Clinical Medicine and Surgery, Federico II University Hospital, Naples, Italy"
      ],
      "name": "Roberto de Sire"
    },
    {
      "affiliations": [
        "Endoscopy Unit, Gastroenterology Department, IRCCS Humanitas Research Hospital, Rozzano, Italy"
      ],
      "name": "Antonio Capogreco"
    },
    {
      "affiliations": [
        "Endoscopy Unit, Gastroenterology Department, IRCCS Humanitas Research Hospital, Rozzano, Italy"
      ],
      "name": "Davide Massimi"
    },
    {
      "affiliations": [
        "Endoscopy Unit, Gastroenterology Department, IRCCS Humanitas Research Hospital, Rozzano, Italy"
      ],
      "name": "Ludovico Alfarone"
    },
    {
      "affiliations": [
        "Department of Biomedical Sciences, Humanitas University, Milan, Italy"
      ],
      "name": "Luca Brandaleone"
    },
    {
      "affiliations": [
        "Department of Biomedical Sciences, Humanitas University, Milan, Italy"
      ],
      "name": "Vincenzo Vadalà"
    },
    {
      "affiliations": [
        "Department of Biomedical Sciences, Humanitas University, Milan, Italy"
      ],
      "name": "Francesco Minini"
    },
    {
      "affiliations": [
        "Endoscopy Unit, Gastroenterology Department, IRCCS Humanitas Research Hospital, Rozzano, Italy"
      ],
      "name": "Spadaccini Marco"
    },
    {
      "affiliations": [
        "Experimental Medicine, Università del Salento, Lecce, Italy"
      ],
      "name": "Antonio Facciorusso"
    },
    {
      "affiliations": [
        "Gastroenterolgy and Hepatology Center, Al-Amiri Hospital, Kuwait City, Kuwait"
      ],
      "name": "Asma Alkandari"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Portsmouth Hospitals University NHS Trust, Portsmouth, England, UK"
      ],
      "name": "Pradeep Bhandari"
    },
    {
      "affiliations": [
        "Endoscopy Unit, Gastroenterology Department, IRCCS Humanitas Research Hospital, Rozzano, Italy",
        "Department of Biomedical Sciences, Humanitas University, Milan, Italy"
      ],
      "name": "Cesare Hassan"
    },
    {
      "affiliations": [
        "Endoscopy Unit, Gastroenterology Department, IRCCS Humanitas Research Hospital, Rozzano, Italy",
        "Department of Biomedical Sciences, Humanitas University, Milan, Italy"
      ],
      "name": "Roberta Maselli"
    },
    {
      "affiliations": [
        "Endoscopy Unit, Gastroenterology Department, IRCCS Humanitas Research Hospital, Rozzano, Italy",
        "Department of Biomedical Sciences, Humanitas University, Milan, Italy"
      ],
      "name": "Alessandro Repici"
    }
  ],
  "title": "Underwater endoscopic submucosal dissection for large non-pedunculated colorectal polyps",
  "uid": "26cc9513-f165-5ac4-b107-551cbc0e21c2"
}