{
  "abstract": "In 2022, the gastro-oesophageal junctional zone (GOJZ) was proposed at the International Consensus Conference in Kyoto as the area extending 1 cm proximally and 1 cm distally from the gastro-oesophageal junction (GOJ), defined by the distal end of the palisade vessels (DEPV).1 2 The definition of GOJ remains a matter of debate. In the globally recognised GOJ cancer classification, a Siewert type II tumour is an adenocarcinoma located 1 cm above to 2 cm below the GOJ, representing a ‘true carcinoma of the cardia’.3 Although the distribution of cardiac glands should determine GOJZ, distinction between native cardiac glands and metaplastic changes at the GOJZ remains a histological challenge due to conventional H&E staining limitations. The previous studies failed to differentiate between pyloric/pseudopyloric metaplasia and cardiac or oxyntocardiac glands, as they did not use immunohistochemical stainings of pepsinogen I (PPGI).",
  "authors": [
    {
      "affiliations": [
        "Endoscopy Center, Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Japan",
        "2nd Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan"
      ],
      "name": "Kazuhiro Ota"
    },
    {
      "affiliations": [
        "Education center for medicine and nursing, Shiga University of Medical Science, Otsu, Japan"
      ],
      "name": "Ken-ichi Mukaisho"
    },
    {
      "affiliations": [
        "Digestive Diseases Center, Showa University Koto Toyosu Hospital, Koto, Japan"
      ],
      "name": "Yuto Shimamura"
    },
    {
      "affiliations": [
        "Department of Pathology, The University of Tokyo, Bunkyo, Japan"
      ],
      "name": "Tetsuo Ushiku"
    },
    {
      "affiliations": [
        "Department of Pathology, Osaka Medical and Pharmaceutical University, Takatsuki, Japan"
      ],
      "name": "Mitsuaki Ishida"
    },
    {
      "affiliations": [
        "Endoscopy Center, Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Japan",
        "2nd Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan"
      ],
      "name": "Shun Sasaki"
    },
    {
      "affiliations": [
        "2nd Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan"
      ],
      "name": "Taro Iwatsubo"
    },
    {
      "affiliations": [
        "Endoscopy Center, Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Japan",
        "2nd Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan"
      ],
      "name": "Noriaki Sugawara"
    },
    {
      "affiliations": [
        "2nd Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan"
      ],
      "name": "Akitoshi Hakoda"
    },
    {
      "affiliations": [
        "2nd Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan"
      ],
      "name": "Hiroki Nishikawa"
    },
    {
      "affiliations": [
        "2nd Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan"
      ],
      "name": "Kazuhide Higuchi"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, The University of Tokyo, Tokyo, Japan"
      ],
      "name": "Mitsuhiro Fujishiro"
    },
    {
      "affiliations": [
        "Cancer Institute Hospital Gastroenterology Center, Koto, Japan"
      ],
      "name": "Takuji Gotoda"
    },
    {
      "affiliations": [
        "Tama Ryokuseikai Byoin, Kodaira, Japan"
      ],
      "name": "Michio Kaminishi"
    },
    {
      "affiliations": [
        "Jichi Medical University, Shimotsuke, Japan"
      ],
      "name": "Kentaro Sugano"
    }
  ],
  "title": "Validation of the definition of gastro-oesophageal junctional zone: an immunohistochemical study using resected mucosal specimens",
  "uid": "a366d589-caeb-56e7-9b8d-44c603a3e508"
}