{
  "abstract": "Metabolic dysfunction-associated steatotic liver disease (MASLD) has risen in prevalence in parallel with obesity over the past decade. Current clinical guidelines emphasise the importance of a prudent diet to mitigate an unfavourable prognosis. Little is known on the relationship between limited or uncertain access to nutritious food as experienced during food insecurity and MASLD. This review aimed to summarise and synthesise available data on the association between MASLD and food insecurity and the association between food insecurity and severity of disease in people with MASLD.A systematic review was conducted across four databases: Ovid MEDLINE, EMBASE, Web of Science and CINAHL, up to April 2024. Any design of observational study whose participants were adults or children over 2 years of age, with food security status assessed via a validated tool, and MASLD or previous nomenclature defined by clinical diagnosis or estimated by robust diagnostic criteria were eligible. PROSPERO CRD42024532764.The clinical heterogeneity of the included thirteen full text studies and nine abstracts precluded meta-analysis. All studies, except one, originated from the USA and all data on MASLD and food insecurity were cross-sectional regardless of study design. Twenty of the studies used the gold standard USDA Household Food Security Survey tool for food insecurity assessment. Non-invasive tests were used in most studies to screen for the presence of MASLD or MASLD with fibrosis. Seven of the ten studies with relevant data reported odds ratios for MASLD in those who were food insecure ranging from 1.38 (95% CI:1.08, 1.77) to 3.70 (95% CI:1.50, 9.00) compared to food secure individuals, see figure 1. Four of the eleven studies containing data that reported on food security status among people with MASLD, indicated that those who were food insecure had significantly increased odds of MASLD with fibrosis compared to those who were food secure, adjusted odds ratios ranged from 2.2 (95% CI:1.27, 3.82) to 5.50 (95% CI: 1.31, 23.10).These results indicate food insecurity is significantly associated with MASLD and potentially more advanced disease. To ensure health equity and prevent unnecessary disease progression in MASLD patients, food insecurity screening in clinical settings coupled with public health programmes to facilitate food and nutrition security in communities in need are warranted.Abstract P119 Figure 1Association between food insecurity and odds of MASLD. Adjusted odds ratios are shown for all studies except those in blue where data only allowed for calculation of a crude ratio",
  "authors": [
    {
      "affiliations": [
        "University Of Southampton, Southampton, UK"
      ],
      "name": "Patricia Treseder-Griffin"
    },
    {
      "affiliations": [
        "University Of Southampton, Southampton, UK",
        "University Hospital Southampton Hepatology, Southampton, UK"
      ],
      "name": "Ryan Buchanan"
    },
    {
      "affiliations": [
        "University Of Southampton, Southampton, UK"
      ],
      "name": "Kate Glyn-Owen"
    }
  ],
  "title": "P119 The association between metabolic dysfunction-associated steatotic liver disease and food insecurity in adults and children – a systematic review",
  "uid": "5509b544-68d1-5fc4-9396-6e6a797cac67"
}