{
  "abstract": "We have recently reported the immune-promoting effects of butyrate in microsatellite stable (MSS) colorectal cancer (CRC) based on mouse models.1 However, its potential application in human CRC and the underlying mechanisms by which butyrate interacts with specific CD8+ T cell subsets to regulate immunity in MSS-CRC warrant further investigation.",
  "authors": [
    {
      "affiliations": [
        "Department of Gastrointestinal Surgery, Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China"
      ],
      "name": "Yongxin Zhang"
    },
    {
      "affiliations": [
        "Department of Gastrointestinal-Pancreatic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China"
      ],
      "name": "Wu Song"
    },
    {
      "affiliations": [
        "Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China"
      ],
      "name": "Lei Zhou"
    },
    {
      "affiliations": [
        "Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China"
      ],
      "name": "Shuwen Wei"
    },
    {
      "affiliations": [
        "Department of Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China"
      ],
      "name": "Lixia Xu"
    },
    {
      "affiliations": [
        "Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China"
      ],
      "name": "Xiaoxing Li"
    },
    {
      "affiliations": [
        "Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong"
      ],
      "name": "Jun Yu"
    }
  ],
  "title": "Bacteria-metabolite butyrate boosts anti-PD1 efficacy in colorectal cancer patient-derived organoids through activating autologous tumour-infiltrating GNLY\n+CD8+ T cells",
  "uid": "c3f11ae7-c9e1-5cfc-8467-52cfd77d7aae"
}