{
  "abstract": "Background Hepatocellular carcinoma (HCC) is a significant global cancer burden, with rising incidence and lacking a unified prevention strategy due to complex aetiologies. Viral exposures may shape host immunity via specific reactive viral antigens that could induce immune responses against hepatocarcinogenesis.Objective We aimed to characterise viral exposure differences between HCC patients and healthy individuals and identify potentially protective viral antigens against HCC.Design We profiled pan-viral serological antibody repertoires using a microbial phage library among 2647 study subjects and examined the biological activities of selective viral antigens on blood-derived immune cells from both healthy individuals and HCC patients.Result We identified 153 viral antigens with a significantly reduced serological response in HCC patients compared with healthy individuals. We also observed that a higher serological response to 153 viral antigens is associated with better clinical outcomes of patients with chronic liver diseases and HCC. These findings are consistent across different populations across sex, ethnicity and aetiology. We identified a common epitope (CE1) shared among 39% of reactive viral antigens that belong to the rhinovirus and enterovirus families. We demonstrated that CE1 could induce both CD4 + and CD8+ T-cell activation and CD8+ T-cell-mediated HCC cell killing.Conclusions Our results suggest that past exposures to members of the Enterovirus genus may be advantageous for cancer patients, highlighting the potential for a viral peptide-based HCC vaccine.",
  "authors": [
    {
      "affiliations": [
        "Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA",
        "Liver Cancer Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA",
        "Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA"
      ],
      "name": "Lichun Ma"
    },
    {
      "affiliations": [
        "Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA"
      ],
      "name": "Man Hsin Hung"
    },
    {
      "affiliations": [
        "Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA"
      ],
      "name": "Farid Rashidi Mehrabadi"
    },
    {
      "affiliations": [
        "Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA"
      ],
      "name": "Limin Wang"
    },
    {
      "affiliations": [
        "Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA"
      ],
      "name": "Qin Li"
    },
    {
      "affiliations": [
        "Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA"
      ],
      "name": "Marshonna Forgues"
    },
    {
      "affiliations": [
        "Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA"
      ],
      "name": "Kathy Cheng Wang"
    },
    {
      "affiliations": [
        "Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA",
        "Liver Cancer Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA"
      ],
      "name": "Anuradha Budhu"
    },
    {
      "affiliations": [
        "Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA",
        "Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA"
      ],
      "name": "Julián Candia"
    },
    {
      "affiliations": [
        "Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute, Bangkok, Thailand",
        "Center of Excellence on Environmental Health and Toxicology (EHT), OPS, MHESI, Bangkok, Thailand"
      ],
      "name": "Jittiporn Chaisaingmongkol"
    },
    {
      "affiliations": [
        "Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute, Bangkok, Thailand"
      ],
      "name": "Siritida Rabibhadana"
    },
    {
      "affiliations": [
        "Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute, Bangkok, Thailand"
      ],
      "name": "Benjarath Pupacdi"
    },
    {
      "affiliations": [
        "Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute, Bangkok, Thailand",
        "Center of Excellence on Environmental Health and Toxicology (EHT), OPS, MHESI, Bangkok, Thailand"
      ],
      "name": "Mathuros Ruchirawat"
    },
    {
      "affiliations": [
        "Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA",
        "Liver Cancer Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA"
      ],
      "name": "Xin Wei Wang"
    }
  ],
  "title": "Beneficial infections of the enterovirus genus in patients with liver cancer",
  "uid": "5a7b3796-a8d6-5dca-8601-0f76b723e403"
}