{
  "abstract": "Ovarian cancer recurs in approximately 70% of cases. In platinum-sensitive relapse, platinum-based therapy remains the backbone of treatment, with optional integration of secondary cytoreductive surgery achieving complete resection and/or hyperthermic intraperitoneal chemotherapy, although evidence remains conflicting. Bevacizumab combined with chemotherapy improves progression-free survival (PFS) but not overall survival (OS). Poly(ADP-ribose) polymerase inhibitor (PARPi) maintenance significantly prolongs PFS in patients with germline or somatic BRCA mutations; its use is currently restricted to this subgroup. Immune checkpoint inhibitors have failed to demonstrate benefit in phase III trials.In platinum-resistant ovarian cancer (PROC), platinum rechallenge retains activity in selected patients. Bevacizumab with chemotherapy improves PFS without OS benefit. Novel antibody-drug conjugates (ADCs) are emerging as promising options: mirvetuximab soravtansine significantly improved PFS (5.6 vs 4.0 months) and OS (16.5 vs 12.8 months) compared with chemotherapy in folate receptor alpha-high PROC (MIRASOL). Trastuzumab deruxtecan has shown high response rates in HER2-expressing disease. Other ADCs and targeted agents, including the WEE1 inhibitor adavosertib, are currently under evaluation.Biomarker-driven therapies are reshaping the management of recurrent ovarian cancer. Future strategies should prioritise improved patient selection and earlier integration of targeted therapies.",
  "authors": [
    {
      "affiliations": [
        "Department of Gynaecology and Obstetrics, Division of Women’s and Children’s Health, University of Padova, Padova, Italy"
      ],
      "name": "Orazio De Tommasi"
    },
    {
      "affiliations": [
        "Department of Gynecology, Southern University of Science and Technology Hospital, Shenzhen, Guangdong, China"
      ],
      "name": "Hongxin Pan"
    },
    {
      "affiliations": [
        "Department of Gynaecology and Obstetrics, Division of Women’s and Children’s Health, University of Padova, Padova, Italy"
      ],
      "name": "Giulia Spagnol"
    },
    {
      "affiliations": [
        "Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy"
      ],
      "name": "Davide Massa"
    },
    {
      "affiliations": [
        "Department of Gynaecology and Obstetrics, Division of Women’s and Children’s Health, University of Padova, Padova, Italy"
      ],
      "name": "Nicola Marconato"
    },
    {
      "affiliations": [
        "Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy"
      ],
      "name": "Giosuè Giordano Incognito"
    },
    {
      "affiliations": [
        "Department of Gynaecology and Obstetrics, Division of Women’s and Children’s Health, University of Padova, Padova, Italy"
      ],
      "name": "Sofia Bigardi"
    },
    {
      "affiliations": [
        "Department of Gynaecology and Obstetrics, Division of Women’s and Children’s Health, University of Padova, Padova, Italy"
      ],
      "name": "Riccardo Toniato"
    },
    {
      "affiliations": [
        "Department of Gynaecology and Obstetrics, Division of Women’s and Children’s Health, University of Padova, Padova, Italy"
      ],
      "name": "Angelica Basso"
    },
    {
      "affiliations": [
        "Department of Gynaecology and Obstetrics, Division of Women’s and Children’s Health, University of Padova, Padova, Italy"
      ],
      "name": "Carlo Saccardi"
    },
    {
      "affiliations": [
        "Department of Gynaecology and Obstetrics, Division of Women’s and Children’s Health, University of Padova, Padova, Italy"
      ],
      "name": "Marco Noventa"
    },
    {
      "affiliations": [
        "Department of Gynaecology and Obstetrics, Division of Women’s and Children’s Health, University of Padova, Padova, Italy",
        "Padova University, Padova, Italy",
        "Clinic of Gynecology and Obstetrics, University of Padua, Padova, Italy"
      ],
      "name": "Roberto Tozzi"
    }
  ],
  "title": "New frontiers in the management of recurrent epithelial ovarian cancer: a comprehensive review",
  "uid": "e39bb389-ef7e-5aad-8966-87ba3a5546bf"
}