{
  "abstract": "Before the 1960’s children with intestinal failure (IF) did not survive. The landmark creation of parenteral nutrition (PN) and further advancements in clinical practice has now made survival a common phenomenon. Regrettably, other complications have emerged including metabolic bone disease, increase fat mass and lower muscle mass compared to healthy children.The aim of this study was to compare body composition (BC) between children on PN and those weaned off PN in a single tertiary IF centre.Children attending the IF clinic aged 5-16 years had their BC analysed using the Tanita MC-780MA-N Pro body composition scales. The scale measured the percentages of body fat (BF), muscle mass, skeletal muscle mass, body water and bone mass using sarcopenic index (SI).21 children had their BC analysed, 10 were on PN (7 males) and 11 off PN (9 males). The median age of those on PN was 11.8 years [IQR 9.4 and 14.8] and 14.4 years [IQR 12.6-15.4] for those off PN. All 11 patients that had come off PN had short bowel syndrome (SBS) and of those still on PN, 6/10 had SBS, 2/10 dysmotility and 2/10, enteropathy.Those on PN received a median of 64% [IQR 39.7-81.8] of their estimated average requirement (EAR) from PN, had a median BMI of 15.6kg/m2 [IQR 15-16.3], z score for weight of -0.89 [IQR -1.65 to -0.14] and z score for height -0.61 [IQR -1.87-0.26]. Those off PN had a median BMI of 16kg/m2 [IQR 14.2-17.3], z score for weight -1.58 [IQR-2.47 - 0.05] and z score for height -0.72 [IQR -1.60 - -0.05].Table one shows the body composition of those on and off PN and those on more than 80% of their energy from PN versus those on less than 80% of energy from PN.Children that came off PN had less body fat, increased muscle mass, and increased bone density compared to children still on PN. Those that were off PN or < 80% PN had statistically significant better bone density and hydration compared to those on >80% PN.Children who achieve enteral autonomy have healthier body composition compared those still on PN. Benefits can be seen in bone mass and hydration in those that require less than 80% of PN indicating that even if total enteral autonomy can’t be achieved, less PN equals greater benefit for hydration and bone mass.Abstract OC7 Table 1Body composition of those on and off PN and those on < 80% PN vs. < 80% PN or off PNMedianOn PNOff PNp value% BF18.8 [IQR 15.4-24.5]14.1 [IQR 12.1-17.4]0.057% muscle mass76.8 [IQR 71.3 – 80.1]81 [IQR 78.4-83.2]0.062% skeletal muscle mass46 [IQR 42.7-47.9]48.6 [IQR 46.7-49.7]0.057Bone mass (SI)4.76 [IQR 4.13-5.55]5.41 [IQR 4.5-5.54]0.457Mean> 80% PN (n-2)< 80% PN or Off PN (n=19)Bone mass (SI)3.83 (SD 0.38)5.13 (SD 0.71)0.034% body water56% (SD 1.48)62.4 % (SD 3.77)0.037",
  "authors": [
    {
      "affiliations": [
        "The Leeds Teaching Hospitals, Leeds Children’s Hospitals"
      ],
      "name": "Julie Steele"
    },
    {
      "affiliations": [
        "The Leeds Teaching Hospitals, Leeds Children’s Hospitals"
      ],
      "name": "Leanne Fawcett"
    },
    {
      "affiliations": [
        "The Leeds Teaching Hospitals, Leeds Children’s Hospitals"
      ],
      "name": "Elena Cernat"
    },
    {
      "affiliations": [
        "The Leeds Teaching Hospitals, Leeds Children’s Hospitals"
      ],
      "name": "Charlotte Hewitson"
    }
  ],
  "title": "OC7 It’s what’s on the inside that counts – body composition in children with intestinal failure",
  "uid": "68f45812-141f-5eed-97fc-2e4c2461e5c7"
}