{
  "abstract": "Historically, Coeliac Disease has been considered as an important cause of linear growth faltering in children, and effective treatment has been associated with linear catch-up growth. However, with modern, readily available diagnostics tests, and increased awareness, Coeliac is being diagnosed at an earlier stage in the disease course. Hence, we wondered if effective treatment of Coeliac would still be associated with linear catch-up growth.We did a retrospective analysis of routine clinical data captured in electronic patient records of patients with an identified diagnosis of Coeliac Disease at a single centre. We extracted baseline demographic and clinical data, and anthropometric and laboratory data at 12, and 24 months after diagnosis. We focussed on height-for-age Z-score as a standardised index of linear growth, and the change in HAZ from diagnosis to 2 years post diagnosis (dHAZ-2y) as an index of catch-up growth. Data were fully anonymised and no ethical approval was required. Standard non-parametric testing, paired t-tests, and linear regression analyses were undertaken in Prism.50 patients were included in the analysis. There was a modest degree of growth faltering at diagnosis, as the population mean HAZ was -0.45 (95% CI: -0.85 - -0.05). Across the population as a whole, there was no evidence of significant change in HAZ from diagnosis to 1, or 2 years, post-diagnosis. dHAZ-2y was inversely associated with baseline HAZ (Y = -0.29*X + 0.08; R2 = 0.18; p = 0.004), suggesting regression to the mean over time. Considering patients who had normalised IgA-TTG at 1 year (n=27), versus those with persistently elevated IgA-TTG (n=13), there was no significant difference in terms of dHAZ-2y.There is evidence of a modest degree of growth faltering at diagnosis, but we failed to identify a significant degree of linear catch-up growth during treatment of newly-diagnosed Coeliac Disease regardless of normalisation of IgA-TTG.",
  "authors": [
    {
      "affiliations": [
        "Great Ormond Street Hospital for Children"
      ],
      "name": "Maria Kleitsioti"
    },
    {
      "affiliations": [
        "Barts Health NHS Trust"
      ],
      "name": "Leila D S Costa"
    },
    {
      "affiliations": [
        "Great Ormond Street Hospital for Children"
      ],
      "name": "Fevronia Kiparissi"
    },
    {
      "affiliations": [
        "Great Ormond Street Hospital for Children"
      ],
      "name": "Edward Gaynor"
    },
    {
      "affiliations": [
        "Great Ormond Street Hospital for Children"
      ],
      "name": "Kelsey DJ Jones"
    },
    {
      "affiliations": [
        "Great Ormond Street Hospital for Children"
      ],
      "name": "Lauren Arpe"
    }
  ],
  "title": "OC64 Coeliac disease treatment may not be associated with linear catch-up growth in the modern era",
  "uid": "144e7fd9-1d75-547f-9200-2a9ad8f7569a"
}