{
  "abstract": "Following a concern raised to NHS England’s National Patient Safety Team regarding tranexamic acid use in gastrointestinal bleeding, and in light of the 2020 publication of the HALT-IT trial results, we are providing this position statement. Tranexamic acid (TXA) is an antifibrinolytic agent that inhibits the breakdown of fibrin clots by blocking plasminogen activation. Its efficacy in reducing bleeding and mortality has been demonstrated in trauma patients (CRASH-2) and in reducing bleeding in surgical patients. 1 2 Systematic review of small older randomised trials in upper GI bleeding suggested that TXA might reduce mortality.3 However, these trials had methodological weaknesses and were conducted before routine use of modern therapies (such as proton-pump inhibitors and endoscopic haemostasis).4 The 2018 BSG guidelines on acute lower gastrointestinal bleeding recommended TXA use was confined to clinical trials, pending the HALT-IT trial results.5",
  "authors": [
    {
      "affiliations": [
        "Department of Gastroenterology, Sandwell and West Birmingham NHS Trust, Hallam Street, West Bromwich, UK"
      ],
      "name": "Nigel Trudgill"
    },
    {
      "affiliations": [
        "Colorectal Surgery, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK"
      ],
      "name": "Katie Yeadon"
    },
    {
      "affiliations": [
        "Division of Clinical Medicine, School of Medicine and Population Health, The University of Sheffield, Sheffield, UK",
        "Department of Gastroenterology, Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"
      ],
      "name": "Matthew Kurien"
    },
    {
      "affiliations": [],
      "name": "On behalf of the British Society of Gastroenterology and the Association of Coloproctology of Great Britain and Ireland"
    }
  ],
  "title": "British Society of Gastroenterology and Association of Coloproctology of Great Britain and Ireland position on tranexamic acid in upper and lower gastrointestinal bleeding",
  "uid": "abc0f912-d241-58ff-8b37-0cc7f542c9e6"
}