{
  "abstract": "Eosinophilic hepatitis is a rare manifestation of hypereosinophilic syndrome (HES), typically requiring exclusion of infectious, drug-induced, autoimmune and neoplastic causes. We report the case of a 54-year-old woman who developed recurrent episodes of acute cholestatic hepatitis with severe peripheral eosinophilia. Despite corticosteroid responsiveness, the patient experienced relapses and intolerance to azathioprine. Introduction of mepolizumab, an anti-IL-5 monoclonal antibody, led to sustained clinical remission, normalisation of eosinophil counts and marked histological improvement, enabling steroid discontinuation. This case underscores the importance of considering HES in the differential diagnosis of eosinophilic liver infiltration and the potential role of mepolizumab as a safe and effective steroid-sparing agent in eosinophilic hepatitis.",
  "authors": [
    {
      "affiliations": [
        "Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"
      ],
      "name": "Antonino Marcello Pilia"
    },
    {
      "affiliations": [
        "Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy",
        "Immunology and Cell Therapy Unit, University Hospital Careggi, Florence, Italy"
      ],
      "name": "Lorenzo Salvati"
    },
    {
      "affiliations": [
        "Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy",
        "Immunology and Cell Therapy Unit, University Hospital Careggi, Florence, Italy"
      ],
      "name": "Marco Del Carria"
    },
    {
      "affiliations": [
        "Department of Pathology, Azienda Ospedaliera Universitaria Senese, Siena, Italy"
      ],
      "name": "Domenico Ferrara"
    },
    {
      "affiliations": [
        "Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy",
        "Diagnostic Center of Flow Cytometry and Immunology, University Hospital Careggi, Florence, Italy"
      ],
      "name": "Alessio Mazzoni"
    },
    {
      "affiliations": [
        "Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"
      ],
      "name": "Giulia Micheli"
    },
    {
      "affiliations": [
        "Section of Pathology, University of Siena, Siena, Italy"
      ],
      "name": "Lorenzo Leoncini"
    },
    {
      "affiliations": [
        "Department of Human Pathology and Oncology, University of Florence, Florence, Italy"
      ],
      "name": "Luca Messerini"
    },
    {
      "affiliations": [
        "Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"
      ],
      "name": "Fabio Marra"
    },
    {
      "affiliations": [
        "Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"
      ],
      "name": "Paola Parronchi"
    }
  ],
  "title": "Eosinophilic hepatitis successfully treated with mepolizumab",
  "uid": "ba7d0802-375a-57a9-a4b4-7e068f39fe66"
}