{
  "abstract": "Ultra-processed foods (UPFs) are widely consumed due to their affordability and convenience, yet they are associated with adverse health outcomes, including gastrointestinal diseases. 1 The incidence of Crohn’s Disease (CD) has been increasing in regions with rising UPF intake.2 This study aims to evaluate dietary factors, specifically UPF consumption, in relation to remission duration and demographic factors in paediatric CD patients following successful exclusive enteral nutrition (EEN) induction. The primary objective is to determine the relationship between UPF intake, captured via a one-time food frequency questionnaire, and remission duration (days) in this cohort. Secondary objectives include analysing UPF consumption across ethnicity and socioeconomic backgrounds.We conducted an observational cohort study in CD patients (≤18 years) diagnosed between April 2023 and April 2024 and successfully treated with EEN at a specialised centre. Data were collected via a questionnaire and the patients’ electronic records, and statistical analysis was performed in IBM SPSS statistics version 29.11 participants (six female) were included in the cohort; median (IQR) age was 13 (7–18), 54.5% had ileal disease, 100% had a non-stricturing non-penetrating phenotype, 45% had upper GI disease,18.2% had perianal disease, 45.4% were Asian/Asian British, and 63.6% were from low socioeconomic backgrounds. Six patients relapsed post-EEN, and mean remission length was 62.7% lower in the relapse group. Table 1 summarises the cohort’s dietary patterns. Mean UPF consumption was higher in the relapse group (42.30, SD 18.96) compared to the remission group (38.64, SD 13.95), but no statistically significant association was found between UPF intake and remission duration (Cox regression, fully adjusted model: HR 0.93, 95% CI 0.772–1.116, p=0.429). Higher mean UPF consumption was associated with higher socioeconomic status (high; 46.59, SD 7.23, middle; 39.79, SD 28.22, low; 39.18, SD 16.71) and Black/Black British ethnicity (Black/Black British 47.01, SD 15.28, Asian/Asian British 36.68, SD 20.59, Other 40.84, SD 11.19), however this was not statistically proven (Kendall’s Tau correlation coefficient for socioeconomic status 0.191, p=0.463, Kruskal-Wallis, mean ranks; Black/Black British 7.33, Other 6.55, Asian/Asian British 5.00, p=0.970).In conclusion, higher UPF intake was not statistically associated with remission length in children with mild-to-moderate CD post-EEN induction. UPF intake didn’t vary substantially across socioeconomic or ethnic groups. Larger longitudinal studies are needed to clarify the role of UPFs in CD progression before introducing dietary guidelines in clinical practice.Abstract OC31 Table 1Cohort’s dietary patterns and UPF consumption Variables Total (n=11) BMI (kg/m2) Median (Range) 20.2 (14.3–24.8) BMI-for-age (percentile) Median (Range) 75.0 (12.0–98.1) BMI-for-age percentile category (n)Underweight Healthy Weight Overweight Obesity -9 (81.8%)1 (9.1%)1 (9.1%) Total energy consumption (kcal/day) Median (Range) 1878.2 (1198.5–2244.6) UPF consumption (kcal/day) Median (Range) 694.2 (297.9–1411.5) UPF consumption (%) Median (Range) 41.1 (17.2–68.5) Fast food/take away consumption prior to CD diagnosis (servings/day) Mean (SD) 0.35 (0.36) Fast food/take away consumption post CD diagnosis (servings/day) Mean (SD) 0.18 (0.27) Data are presented as n (%) or median (range)/mean (SD).BMI measured after EEN completion.References Ultra-processed foods and food additives in gut health and disease | Nature Reviews Gastroenterology & Hepatology [Internet].Ng SC, Shi HY, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. The Lancet 2017 Dec 23;390(10114):2769–78.",
  "authors": [
    {
      "affiliations": [
        "MSc Gastroenterology, Queen Mary University of London"
      ],
      "name": "Elektra Tsivitanidou"
    },
    {
      "affiliations": [
        "Paediatric Gastroenterology, Barts and the London School of Medicine, London, UK"
      ],
      "name": "Sandhia Naik"
    }
  ],
  "title": "OC31 Response to exclusive enteral nutrition in children with inflammatory bowel disease specifically any differences with ethnicity, demographics rather than just phenotype",
  "uid": "15266685-5e48-5d9e-adda-618f5079169e"
}