{
  "abstract": "Background Gastrointestinal (GI) bleeding is a common event that can be life-threatening. Mussetto et al demonstrated the feasibility of panenteric capsule endoscopy (PCE) in patients with melaena and a negative oesophagogastroduodenoscopy (OGD)—the bleeding source was identified in 80% of patients and colonoscopy was avoided in 50%. However, there are no large prospective trials and limited real-world data.At two tertiary centres in the UK, we retrospectively evaluated the outcomes of patients who underwent an inpatient PCE following a negative OGD for suspected upper GI bleeding.Methods Capsule databases at each institution were reviewed from 2021 to 2024. The inclusion criteria were patients who had a suspected upper GI bleed (melaena and haemoglobin drop of >10 g/L) and underwent an inpatient PCE following a negative OGD. Data was extracted from the patient’s electronic health records.Results 23 patients met the inclusion criteria. The mean age was 56 years. The median time from OGD to capsule ingestion was 4 days. The source of bleeding was identified by PCE in 70% of cases. A small bowel source was identified in 43%. PCE prevented unnecessary lower GI endoscopy in 70%. Capsule retention occurred in 1 patient and was managed conservatively. Rebleeding rates at 30 days, 6 months and 12 months were 9%, 4% and 0%.Conclusion PCE is an option for patients presenting with melaena and has a negative upper GI endoscopy. The findings from this study are promising with a diagnostic yield of 70%. Large, multi-centre randomised studies are required to further investigate this strategy.",
  "authors": [
    {
      "affiliations": [
        "University College London Hospitals NHS Foundation Trust, London, UK"
      ],
      "name": "Jie Han Yeo"
    },
    {
      "affiliations": [
        "Guy's and St Thomas' Hospitals NHS Trust, London, UK"
      ],
      "name": "Xin Yi Choon"
    },
    {
      "affiliations": [
        "University College London Hospitals NHS Foundation Trust, London, UK"
      ],
      "name": "Edward Seward"
    },
    {
      "affiliations": [
        "University College London Hospitals NHS Foundation Trust, London, UK"
      ],
      "name": "Sara McCartney"
    },
    {
      "affiliations": [
        "Guy's and St Thomas' Hospitals NHS Trust, London, UK"
      ],
      "name": "Simon H C Anderson"
    },
    {
      "affiliations": [
        "University College London Hospitals NHS Foundation Trust, London, UK"
      ],
      "name": "Stuart Bloom"
    },
    {
      "affiliations": [
        "University College London Hospitals NHS Foundation Trust, London, UK"
      ],
      "name": "James Willsmore"
    },
    {
      "affiliations": [
        "Guy's and St Thomas' Hospitals NHS Trust, London, UK"
      ],
      "name": "Alexandra Zissimopoulos"
    },
    {
      "affiliations": [
        "University College London Hospitals NHS Foundation Trust, London, UK"
      ],
      "name": "Miguela Villa"
    },
    {
      "affiliations": [
        "Guy's and St Thomas' Hospitals NHS Trust, London, UK"
      ],
      "name": "Dean-Martin Borrow"
    },
    {
      "affiliations": [
        "University College London Hospitals NHS Foundation Trust, London, UK"
      ],
      "name": "Paul Harrow"
    },
    {
      "affiliations": [
        "University College London Hospitals NHS Foundation Trust, London, UK"
      ],
      "name": "Ioanna Parisi"
    }
  ],
  "title": "Panenteric capsule endoscopy in patients with melaena and a negative oesophagogastroduodenoscopy: a multi-centre real-world study",
  "uid": "179b0eb6-e921-5338-95dd-3776b1e15ceb"
}