{
  "abstract": "Group B Streptococcus (GBS) remains a leading cause of neonatal sepsis and meningitis in the UK, with an incidence of around 0.9 per 1000 live births. Early-onset disease usually results from vertical transmission during delivery, while late-onset disease is also acquired through postnatal exposures. GBS disease presents as sepsis, meningitis or pneumonia and leads to death in 6% of affected infants and long-term neurodevelopmental impairment in up to a third of survivors. The current UK prevention strategy of risk-based intra-partum antibiotic prophylaxis has several limitations, including lack of impact on disease burden in infants without associated risk factors and on late-onset disease. Ongoing studies of universal antenatal GBS screening and GBS maternal immunisations, along with a new British Paediatric Surveillance Unit surveillance study to provide updated epidemiological data will help to guide policy and practice.",
  "authors": [
    {
      "affiliations": [
        "Institute for Infection and Immunity, City St George’s University of London, London, UK"
      ],
      "name": "Andrew N Young"
    },
    {
      "affiliations": [
        "Institute for Infection and Immunity, City St George’s University of London, London, UK"
      ],
      "name": "Konstantinos Karampatsas"
    },
    {
      "affiliations": [
        "Institute for Infection and Immunity, City St George’s University of London, London, UK",
        "UK Health Security Agency, London, UK"
      ],
      "name": "Shamez N Ladhani"
    },
    {
      "affiliations": [
        "Healthcare-Associated Infection, Fungal, Antimicrobial Resistance, Antimicrobial Use, and Sepsis Division, UK Health Security Agency, London, UK"
      ],
      "name": "Theresa L Lamagni"
    },
    {
      "affiliations": [
        "Institute for Infection and Immunity, City St George’s University of London, London, UK"
      ],
      "name": "Kirsty Le Doare"
    },
    {
      "affiliations": [
        "Institute for Infection and Immunity, City St George’s University of London, London, UK"
      ],
      "name": "Joseph Peacock"
    },
    {
      "affiliations": [
        "Institute for Infection and Immunity, City St George’s University of London, London, UK"
      ],
      "name": "Natasha Thorn"
    },
    {
      "affiliations": [
        "Institute for Infection and Immunity, City St George’s University of London, London, UK"
      ],
      "name": "Paul T Heath"
    }
  ],
  "title": "Current knowledge and future perspectives on management and prevention of group B streptococcus in neonates and young infants",
  "uid": "8e03f389-6e77-5bb4-8d1a-83beaefba765"
}