{
  "abstract": "Background It has traditionally been considered that mother-infant ABO incompatibility only causes mild haemolytic disease of the newborn (HDN). However, this view is inconsistent with clinical practice, and large-scale population-based data are lacking to investigate its effects on neonates.Methods Differences in hospitalisation rates and incidence rates of neonatal hyperbilirubinaemia (NHB) and anaemia among 47 679 Chinese liveborn neonates with different mother-infant ABO combinations, differences in the incidence of ABO-incompatible HDN (ABO-HDN) among neonates with O-B versus O-A mother-infant ABO incompatibility, and the contributions of ABO-HDN to the development of NHB and neonatal anaemia were analysed.Results Of the 47 679 liveborn neonates, neonates with mother-infant ABO incompatibility had higher rates of hospitalisation and incidence of NHB and anaemia. The hierarchy of the risk of mother-infant ABO incompatibility to the neonate was O-B > O-A > non-O-A/O-B incompatibility. Among neonates with O-B and O-A mother-infant ABO incompatibility, the ABO-HDN incidence rates were 15.27% (513/3359) and 11.33% (417/3680), respectively (95% CI 1.41 (1.23 to 1.62)), and the severe ABO-HDN incidence rates were 2.05% (69/3359) and 1.14% (42/3680), respectively (95% CI 1.82 (1.23 to 2.67)). Among the 7039 neonates with O-A/O-B mother-infant ABO incompatibility, ABO-HDN was an independent aetiological factor in 41.11% (666/1620) of the neonates with NHB, 70.27% (52/74) of the neonates with severe NHB, 42.34% (163/385) of the neonates with anaemia and 18.28% (17/93) of the neonates with severe anaemia.Conclusions Mother-infant ABO incompatibility often leads to severe HDN and is a dominant cause of NHB and neonatal anaemia, leading to significantly higher neonatal hospitalisation rates.",
  "authors": [
    {
      "affiliations": [
        "Department of Transfusion Medicine, Dongguan Maternal and Child Health Hospital, Dongguan, Guangdong, China",
        "Dongguan Key Laboratory for Precision Diagnosis and Blood Management of Immune Hemolytic Diseases, Dongguan Maternal and Child Health Hospital, Dongguan, Guangdong, China",
        "Department of Laboratory Medicine, Dongguan Key Clinical Specialist, Dongguan Maternal and Child Health Hospital, Dongguan, Guangdong, China"
      ],
      "name": "Yuanjun Wu"
    },
    {
      "affiliations": [
        "Department of Transfusion Medicine, Dongguan Maternal and Child Health Hospital, Dongguan, Guangdong, China",
        "Dongguan Key Laboratory for Precision Diagnosis and Blood Management of Immune Hemolytic Diseases, Dongguan Maternal and Child Health Hospital, Dongguan, Guangdong, China"
      ],
      "name": "Ganping Guo"
    },
    {
      "affiliations": [
        "Department of Transfusion Medicine, Dongguan Maternal and Child Health Hospital, Dongguan, Guangdong, China",
        "Dongguan Key Laboratory for Precision Diagnosis and Blood Management of Immune Hemolytic Diseases, Dongguan Maternal and Child Health Hospital, Dongguan, Guangdong, China"
      ],
      "name": "Yinglin Wu"
    },
    {
      "affiliations": [
        "Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Medical University, Dongguan, Guangdong, China"
      ],
      "name": "Liangchang Xiu"
    },
    {
      "affiliations": [
        "Institute of Blood Transfusion and Hematology, Guangzhou Blood Center, Guangzhou Medical University, Guangzhou, Guangdong, China"
      ],
      "name": "Yanli Ji"
    },
    {
      "affiliations": [
        "Department of Neonatology, Dongguan Maternal and Child Health Hospital, Dongguan, Guangdong, China"
      ],
      "name": "Minxu Li"
    },
    {
      "affiliations": [
        "Department of Maternity, Dongguan Maternal and Child Health Hospital, Dongguan, Guangdong, China"
      ],
      "name": "Manna Sun"
    },
    {
      "affiliations": [
        "Department of Maternity, Dongguan Maternal and Child Health Hospital, Dongguan, Guangdong, China"
      ],
      "name": "Xinghe Wang"
    },
    {
      "affiliations": [
        "Department of Neonatology, Dongguan Maternal and Child Health Hospital, Dongguan, Guangdong, China"
      ],
      "name": "Xuejun Ren"
    },
    {
      "affiliations": [
        "Department of Neonatology, Dongguan Maternal and Child Health Hospital, Dongguan, Guangdong, China"
      ],
      "name": "Lan Zhang"
    },
    {
      "affiliations": [
        "Department of Transfusion Medicine, Dongguan Maternal and Child Health Hospital, Dongguan, Guangdong, China"
      ],
      "name": "Jianqun Li"
    },
    {
      "affiliations": [
        "Department of Transfusion Medicine, Dongguan Maternal and Child Health Hospital, Dongguan, Guangdong, China"
      ],
      "name": "Shujie Wu"
    },
    {
      "affiliations": [
        "Department of Transfusion Medicine, Dongguan Maternal and Child Health Hospital, Dongguan, Guangdong, China"
      ],
      "name": "Miaozhen Wen"
    },
    {
      "affiliations": [
        "Centre for Reproductive Medicine, Dongguan Maternal and Child Health Hospital, Dongguan, Guangdong, China"
      ],
      "name": "Jiajun Zeng"
    },
    {
      "affiliations": [
        "Department of Transfusion Medicine, Dongguan Maternal and Child Health Hospital, Dongguan, Guangdong, China"
      ],
      "name": "Qianquan Yuan"
    },
    {
      "affiliations": [
        "Department of Transfusion Medicine, Dongguan Maternal and Child Health Hospital, Dongguan, Guangdong, China"
      ],
      "name": "Zhongying Xie"
    },
    {
      "affiliations": [
        "Department of Neonatology, Dongguan Maternal and Child Health Hospital, Dongguan, Guangdong, China"
      ],
      "name": "Yong Yang"
    }
  ],
  "title": "Effects of mother-infant ABO incompatibility on neonates: a cohort study in the Chinese population",
  "uid": "007002f5-7b1d-5cfe-83e0-e60bb79ab2ab"
}