{
  "abstract": "Rationale Information on lung volume characteristics in infants with clinical signs of respiratory distress immediately after birth is limited.Objectives To assess changes in respiratory dynamics and physiological parameters in infants with and without respiratory distress in the delivery room and to determine the effect of continuous positive airway pressure (CPAP) support.Methods Electrical impedance tomography data were obtained from late preterm and term infants, born via caesarean section in a tertiary referral centre. Changes in the ratio of inspiratory to expiratory time (Ti/Te-ratio), end-expiratory lung impedance (∆EELI), oxygen saturation (SpO 2) and heart rate (HR) over the first 10 min as well as corresponding changes after CPAP application were assessed.Measurements and main results Of 73 infants, 18 (25%) received CPAP after birth (11 not admitted ( CPAP group) and 7 admitted to the neonatal intensive care unit (CPAP/NICU)). Ti/Te ratio differed significantly between groups with the highest values in the CPAP/NICU group, mostly due to a reduced Te. There was no difference in ∆EELI. Similarly, infants in the CPAP/NICU group had lower SpO2 and HR trajectories over time than the other two groups. After CPAP application, ΔEELI increased significantly. There were no changes in Ti/Te ratio, SpO2 and HR after CPAP initiation.Conclusions In infants with more severe respiratory distress, Ti/Te ratio was increased, and SpO 2 and HR were reduced, suggesting that these parameters may serve as early predictors of respiratory failure. Application of CPAP resulted in an immediate increase in EELI, highlighting the importance of early CPAP initiation for infants with respiratory distress.",
  "authors": [
    {
      "affiliations": [
        "Newborn Research, Department of Neonatology, University Hospital and University of Zürich, Zurich, Switzerland",
        "Department of Pediatric Intensive Care and Neonatology, Children’s Hospital of Eastern Switzerland, St. Gallen, Switzerland"
      ],
      "name": "Carina Belting"
    },
    {
      "affiliations": [
        "Newborn Research, Department of Neonatology, University Hospital and University of Zürich, Zurich, Switzerland"
      ],
      "name": "Leandra Ramin-Wright"
    },
    {
      "affiliations": [
        "Department of Mathematics and Statistics, Masaryk University, Brno, Czech Republic"
      ],
      "name": "Andrea Kraus"
    },
    {
      "affiliations": [
        "Department of Anesthesiology and Intensive Care Medicine, Rostock University Medical Center, Rostock, Germany"
      ],
      "name": "Andreas D Waldmann"
    },
    {
      "affiliations": [
        "Newborn Research, Department of Neonatology, University Hospital and University of Zürich, Zurich, Switzerland"
      ],
      "name": "Dirk Bassler"
    },
    {
      "affiliations": [
        "Newborn Research, Department of Neonatology, University Hospital and University of Zürich, Zurich, Switzerland"
      ],
      "name": "Vanessa L Büchler"
    },
    {
      "affiliations": [
        "Newborn Research, Department of Neonatology, University Hospital and University of Zürich, Zurich, Switzerland"
      ],
      "name": "Kaylen Gähwiler"
    },
    {
      "affiliations": [
        "Newborn Research, Department of Neonatology, University Hospital and University of Zürich, Zurich, Switzerland"
      ],
      "name": "Christoph Martin Rüegger"
    },
    {
      "affiliations": [
        "Newborn Research, Department of Neonatology, University Hospital and University of Zürich, Zurich, Switzerland",
        "Newborn Research Munich, Division of Neonatology, Dr von Hauner Children’s Hospital, Ludwig-Maximilians-Universität München, Munich, Germany",
        "German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich, Munich, Germany"
      ],
      "name": "Vincent D Gaertner"
    }
  ],
  "title": "Early postnatal respiratory dynamics in term and late preterm infants with respiratory distress",
  "uid": "1ea4f240-59f9-54eb-be86-6ada94285d10"
}