{
  "abstract": "Objective To determine survival and neurodevelopmental outcomes in the Hypotension in Preterm (HIP) trial.Design Prospective follow-up of infants enrolled in randomised controlled trial.Participants 58 infants born before 28 weeks of gestation with low mean arterial blood pressure.Intervention Random allocation to treatment of low blood pressure values with infusion of dopamine or placebo.Primary outcome Survival without neurodevelopmental impairment to 24 months corrected age (CA).Results The HIP trial stopped early due to logistic and recruitment difficulties. Outcomes were determined for 55 infants (27 in the dopamine group and 28 in the placebo group) at 24 months CA. Survival without impairment was present in 13 (48%) infants in the dopamine group and 7 (25%) infants in the placebo group (OR 2.79 (95% CI 0.89, 8.72); p=0.078). The components of the primary outcome were similarly distributed between the two arms. Mean Bayley composite scores and the frequency of somatic impairments did not differ significantly between groups but infants were shorter and lighter at 2 years of age after dopamine administration.Conclusion In this placebo-controlled trial of the treatment of hypotension in extremely preterm infants, dopamine administration did not increase survival without impairment at 2 years CA. However, the study was not sufficiently powered and a clinically important effect cannot be excluded. The role of inotropic medication in facilitating good outcomes requires further study.",
  "authors": [
    {
      "affiliations": [
        "Institute for Womens Health, University College London, London, UK"
      ],
      "name": "Neil Marlow"
    },
    {
      "affiliations": [
        "Neonatologie, Centre Hospitalier Universitaire Sainte Justine, Montreal, Quebec, Canada"
      ],
      "name": "Keith J Barrington"
    },
    {
      "affiliations": [
        "Neonatal Unit, National Maternity Hospital Neonatal Unit, Dublin, Ireland",
        "University College Dublin School of Medicine, Dublin, Ireland"
      ],
      "name": "Colm Patrick Finbarr ODonnell"
    },
    {
      "affiliations": [
        "Coombe Women and Infants University Hospital, Dublin, Ireland"
      ],
      "name": "Jan Miletin"
    },
    {
      "affiliations": [
        "Neonatology, University Hospitals Leuven, Leuven, Belgium",
        "UZ Leuven, Leuven, Belgium"
      ],
      "name": "Gunnar Naulaers"
    },
    {
      "affiliations": [
        "Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada"
      ],
      "name": "Po-Yin Cheung"
    },
    {
      "affiliations": [
        "Department of Paediatrics, Rotunda Hospital, Dublin, Ireland",
        "Royal College of Surgeons in Ireland Faculty of Medicine and Health Sciences, Dublin, Ireland"
      ],
      "name": "John David Corcoran"
    },
    {
      "affiliations": [
        "RCSI Royal College of Surgeons in Ireland Dublin, Dublin, Ireland"
      ],
      "name": "Afif El-Khuffash"
    },
    {
      "affiliations": [
        "Department of Paediatrics and Child Health, INFANT Centre, University College Cork, Cork, Ireland"
      ],
      "name": "Geraldine B Boylan"
    },
    {
      "affiliations": [
        "Department of Paediatrics and Child Health, INFANT Centre, University College Cork, Cork, Ireland"
      ],
      "name": "Vicki Livingstone"
    },
    {
      "affiliations": [
        "Groupe Hospitalier Cochin-Broca-Hôtel Dieu, AP-HP, Clinical Pharmacology, Paris, France"
      ],
      "name": "Gerard Pons"
    },
    {
      "affiliations": [
        "Institute for the Care of Mother and Child, Third Faculty of Medicine, Charles University, Prague, Czech Republic",
        "Neonatology, Institute for the Care of Mother and Child, Prague, Czech Republic"
      ],
      "name": "Zbyněk Straňák"
    },
    {
      "affiliations": [
        "NICU, UZ Antwerp, Edegem, Belgium"
      ],
      "name": "David Van Laere"
    },
    {
      "affiliations": [
        "Department of Neonatology, Tomas Bata University in Zlin, Zlin, Czech Republic"
      ],
      "name": "Jozef Macko"
    },
    {
      "affiliations": [
        "Department of Pediatrics and Neonatal Care, Ostravska Univerzita, Ostrava, Czech Republic"
      ],
      "name": "Hana Wiedermannova"
    },
    {
      "affiliations": [
        "Department of Paediatrics and Child Health, INFANT Centre, University College Cork, Cork, Ireland"
      ],
      "name": "Eugene M Dempsey"
    },
    {
      "affiliations": [],
      "name": "on behalf of the HIP consortium"
    }
  ],
  "title": "Outcomes of extremely preterm infants who participated in a randomised trial of dopamine for treatment of hypotension (the HIP trial) at 2 years corrected age",
  "uid": "af26cd5c-ac7e-5ad9-a73c-4a0695d3c6fb"
}