{
  "abstract": "Aim To determine how different cord clamping strategies affect cerebral oxygenation in the first 15 min after birth in preterm infants.Methods A post-hoc secondary outcome analysis of a multicentre prospective randomised clinical trial (COSGOD III) conducted between October 2017 and October 2021 in 11 tertiary neonatal intensive care units in six countries in Europe and in Canada. In the present ancillary study, all included premature neonates (<32 weeks gestation) were retrospectively assigned to three groups according to the timing of cord clamping (G1<30 s, G2 30–60 s, G3>30 s). The aim of this study was to evaluate differences in cerebral regional oxygen saturation (crSO 2) and cerebral fractional tissue oxygen extraction (cFTOE) within the first 15 min after birth in preterm neonates based on the timing of cord clamping.Results 572 infants (n=339 (G1), n=164 (G2) and n=69 (G3)) were included in the final ancillary analysis. There were no statistically significant differences in crSO 2 and cFTOE between the three groups. There were no statistically significant differences between the three groups in neonatal morbidities, particularly importantly in the degree of cerebral injury, as measured by any degree of intraventricular haemorrhage or cystic periventricular leukomalacia.Conclusions No significant differences in crSO 2 and cFTOE during the first 15 min after birth were observed; however, some effect may have been modified by protocol-guided titration of supplemental oxygen in the intervention arm. Thus, in our study, we did not find a correlation between deferred cord clamping and improved cerebral oxygenation immediately after birth.Trial registration number NCT03166722.",
  "authors": [
    {
      "affiliations": [
        "University Medical Centre Ljubljana, Ljubljana, Slovenia",
        "Medical Faculty, University of Ljubljana, Ljubljana, Slovenia"
      ],
      "name": "Tina Perme"
    },
    {
      "affiliations": [
        "Division of Gynaecology and Obstetrics, Ljubljanski Univerzitetni Klinicni Center, Ljubljana, Slovenia"
      ],
      "name": "Lilijana Kornhauser Cerar"
    },
    {
      "affiliations": [
        "Department of Pediatrics, Division of Neonatology, Medical University of Graz, Graz, Austria"
      ],
      "name": "Bernhard Schwaberger"
    },
    {
      "affiliations": [
        "Paediatrics, University of Graz, Graz, Austria"
      ],
      "name": "Berndt Urlesberger"
    },
    {
      "affiliations": [
        "Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria"
      ],
      "name": "Christina Helene Wolfsberger"
    },
    {
      "affiliations": [
        "Research Unit for Neonatal Microcirculation and Macrocirculation, Medical University Graz, Graz, Austria"
      ],
      "name": "Nariae Baik"
    },
    {
      "affiliations": [
        "Department of Pediatrics and Adolescent Medicine, Division of Neonatology, Intensive Care and Pediatric Neurology, Medical University Vienna, Vienna, Austria"
      ],
      "name": "Katharina Goeral"
    },
    {
      "affiliations": [
        "Department of Pediatrics II, Neonatology, Medical University of Innsbruck, Innsbruck, Austria"
      ],
      "name": "Marlene Hammerl"
    },
    {
      "affiliations": [
        "Department of Paediatrics and Child Health, University College Cork, Wilton, Ireland",
        "Infant Centre, University College Cork, Wilton, Ireland"
      ],
      "name": "Eugene M Dempsey"
    },
    {
      "affiliations": [
        "Neonatology, Universitätsklinikum Tübingen, Tubingen, Germany"
      ],
      "name": "Laila Springer"
    },
    {
      "affiliations": [
        "Ospedale dei Bambini “V.Buzzi”, Milano, Italy"
      ],
      "name": "Gianluca Lista"
    },
    {
      "affiliations": [
        "II Department of Neonatology, Uniwersytet Medyczny imienia Karola Marcinkowskiego w Poznaniu, Poznan, Poland"
      ],
      "name": "Tomasz Szczapa"
    },
    {
      "affiliations": [
        "Neonatology and Ped Intensive Care, Center of Pediatrics, University of Freiburg, Freiburg, Germany"
      ],
      "name": "Hans Fuchs"
    },
    {
      "affiliations": [
        "II Department of Neonatology, Poznan University of Medical Sciences, Poznan, Poland"
      ],
      "name": "Lukasz Karpinski"
    },
    {
      "affiliations": [
        "Department of Neonatology, Institute for Maternal and Child Health IRCCS \"Burlo Garofolo”, Trieste, Italy"
      ],
      "name": "Jenny Bua"
    },
    {
      "affiliations": [
        "Institute for Medical informatics, Statistics and Documentation, Medical University Graz, Graz, Austria"
      ],
      "name": "Alexander Avian"
    },
    {
      "affiliations": [
        "Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada"
      ],
      "name": "Brenda Hiu Yan Law"
    },
    {
      "affiliations": [
        "Neonatology, Medical University of Vienna, Vienna, Austria"
      ],
      "name": "Julia Buchmayer"
    },
    {
      "affiliations": [
        "Deparment of Pediatrics II, Medical University Innsbruck, Innsbruck, Austria"
      ],
      "name": "Ursula Kiechl-Kohlendorfer"
    },
    {
      "affiliations": [
        "Cork University Maternity Hospital, Cork, Ireland"
      ],
      "name": "Christoph E Schwarz"
    },
    {
      "affiliations": [
        "Neonatology, Children's University Hospital Tuebingen, Tuebingen, Germany"
      ],
      "name": "Kerstin Gruendler"
    },
    {
      "affiliations": [
        "Ospedale dei Bambini Vittore Buzzi, Milano, Italy"
      ],
      "name": "Ilaria Stucchi"
    },
    {
      "affiliations": [
        "Pediatrics, Medical University of Vienna, Vienna, Austria"
      ],
      "name": "Katrin Klebermass-Schrehof"
    },
    {
      "affiliations": [
        "Neonatology, Royal Alexandra Hospital, Edmonoton, Alberta, Canada"
      ],
      "name": "Georg M Schmölzer"
    },
    {
      "affiliations": [
        "Pediatrics, Medical University Graz, Graz, Austria"
      ],
      "name": "Gerhard Pichler"
    },
    {
      "affiliations": [],
      "name": "on behalf of the COSGOD III study group"
    }
  ],
  "title": "Effect of timing of umbilical cord clamping on cerebral regional tissue oxygenation: a secondary analysis of the COSGOD III trial",
  "uid": "11a65976-8aa9-53d3-8e4e-0eefeedee471"
}