{
  "abstract": "Objectives Advanced therapy medicinal products require storage at very low or cryogenic temperatures, creating major organisational challenges for hospital pharmacies. This national survey aimed to describe current practices and organisational models for low and ultra-low temperature storage of these medicines in French hospital pharmacies.Methods A descriptive national survey was conducted using an online questionnaire distributed to members of the French Society for Oncology Pharmacy and its advanced therapy working group. The questionnaire explored medicines managed, storage infrastructures, alternative storage solutions and organisational barriers. Results were analysed descriptively and reported as counts and proportions.Results Thirty-eight pharmacists responded, most of them working in university hospitals (86.8%). Advanced therapy medicinal products were managed in both routine care and clinical trials by 76.3% of respondents. Liquid nitrogen vapour storage was the most frequent modality (89.5%), followed by −80°C freezers (57.9%) and temporary dry shipper storage (31.6%). Storage at −150 °C was reported by 15.8% of respondents. Liquid nitrogen storage relied on a cell therapy unit convention in 47.4% of respondents, while an equal proportion (47.4%) managed it under direct pharmaceutical responsibility: a compliant on-site installation within the hospital pharmacy (31.6%), an autonomously managed tank hosted in a cell therapy unit (10.5%) or subcontracting to another hospital pharmacy (5.3%).Conclusions Ultra-low temperature storage is a key organisational component of the pharmaceutical management of advanced therapy medicinal products. In this national survey of 38 pharmacists, diverse storage models combining cryogenic infrastructures, mechanical freezers and collaborative solutions were reported. Adapting infrastructures and organisational strategies will be essential for hospital pharmacies to support the expected expansion of these therapies while ensuring safe and efficient pharmaceutical management.",
  "authors": [
    {
      "affiliations": [
        "ONCOPHARMA - CHU TIMONE, Assistance Publique—Hopitaux de Marseille, Marseille, France",
        "Société Française de Pharmacie Oncologique (SFPO), Marseille, France"
      ],
      "name": "Bertrand Pourroy"
    },
    {
      "affiliations": [
        "Service Pharmacie - Hopitel Saint Louis, Assistance Publique—Hopitaux de Paris, Paris, France",
        "Société Française de Pharmacie Oncologique (SFPO), Paris, France"
      ],
      "name": "Isabelle Madelaine"
    }
  ],
  "title": "Ultra-low temperature storage of advanced therapy medicinal products in hospital pharmacies: findings from a national survey of French hospital pharmacists",
  "uid": "a5407550-4988-5a9f-98d5-138f9479d975"
}