{
  "abstract": "Precision medicine in antimicrobial therapy is uniquely challenging given that the interplay between drug, pathogen and patient forms a ‘three-body problem’, making prediction of clinical outcomes difficult. The three-body problem in physics and mathematics describes the enormous complexity of predicting the motion of three interacting celestial bodies (originally the Earth, Moon and Sun) due to the non-linear and interdependent forces acting between them.1 While two-body systems admit relatively straightforward analytical solutions and calculations, the introduction of a third body produces instability, sensitivity to initial conditions and chaotic behaviour that defies closed-form prediction.1 At best, an estimation of the motion of these masses is possible, and there remains invariably a degree of mathematical uncertainty.1",
  "authors": [
    {
      "affiliations": [
        "Pharmacy Services, Alberta Health Services, Edmonton, Alberta, Canada"
      ],
      "name": "Jackson J Stewart"
    },
    {
      "affiliations": [
        "Pharmacy Services, Alberta Health Services, Edmonton, Alberta, Canada"
      ],
      "name": "Bruce Dalton"
    }
  ],
  "title": "The antimicrobial ‘three-body problem’",
  "uid": "a2f9775f-d6d6-5597-873e-3e6ac5bf4324"
}