{
  "abstract": "Introduction Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a highly complex procedure involving intensive conditioning regimens, immunosuppressive therapy and extensive supportive care.Objective To assess the impact of a comprehensive pharmaceutical care programme on medication adherence in allo-HSCT patients. Early survival and clinical and patient-reported outcomes will also be explored.Methods and analysis Prospective interventional study with a historical control group. The primary outcome is medication adherence. Secondary outcomes will include the incidence of grade I–IV acute graft-versus-host disease (aGVHD); acute graft-versus-host disease-free, relapse-free survival (aGRFS); relapse-free survival (RFS) and overall survival (OS) by day+100; hospital readmissions; acute renal and liver failure; engraftment time; drug-related problems (DRPs); pharmaceutical interventions and patient-reported outcomes. Patients will be enrolled over a 12-month period in the intervention group and compared with a historical cohort of patients undergoing allo-HSCT. The intervention will include a structured pharmacist-led programme including: (1) a pre-admission interview, (2) in-hospital follow-up with daily medication review and DRP identification, (3) patient education at discharge and (4) post-transplant pharmaceutical follow-up to day+100.Ethics and dissemination The study protocol was approved by the hospital Clinical Research Ethics Committee (CEIm code: 245/23). Written informed consent will be obtained from all participants. Data will be handled in accordance with the EU General Data Protection Regulation (2016/679) and Spanish Organic Law 3/2018 on Data Protection and Digital Rights.",
  "authors": [
    {
      "affiliations": [
        "Department of Hospital Pharmacy, Ramón y Cajal University Hospital, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain",
        "Department of Pharmacology, Pharmacognosy and Botany, Universidad Complutense de Madrid, Madrid, Spain"
      ],
      "name": "Paula Guijarro-Martínez"
    },
    {
      "affiliations": [
        "Department of Hospital Pharmacy, Ramón y Cajal University Hospital, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain"
      ],
      "name": "Marina Sánchez-Cuervo"
    },
    {
      "affiliations": [
        "Department of Hospital Pharmacy, Ramón y Cajal University Hospital, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain"
      ],
      "name": "Maria Ángeles Parro-Martín"
    },
    {
      "affiliations": [
        "Department of Hospital Pharmacy, Ramón y Cajal University Hospital, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain"
      ],
      "name": "Elena Gómez Bayona"
    },
    {
      "affiliations": [
        "Haematology and Hemotherapy Department, Ramón y Cajal University Hospital, IRYCIS, Madrid, Spain"
      ],
      "name": "Alejandro Luna de Abia"
    },
    {
      "affiliations": [
        "Haematology and Hemotherapy Department, Ramón y Cajal University Hospital, IRYCIS, Madrid, Spain"
      ],
      "name": "Anabelle Chinea Rodríguez"
    },
    {
      "affiliations": [
        "Haematology and Hemotherapy Department, Ramón y Cajal University Hospital, IRYCIS, Madrid, Spain"
      ],
      "name": "Pilar Herrera Puente"
    },
    {
      "affiliations": [
        "Haematology and Hemotherapy Department, Ramón y Cajal University Hospital, IRYCIS, Madrid, Spain"
      ],
      "name": "Begoña Hinojo Marín"
    },
    {
      "affiliations": [
        "Haematology and Hemotherapy Department, Ramón y Cajal University Hospital, IRYCIS, Madrid, Spain"
      ],
      "name": "Gema Nova Ruiz"
    },
    {
      "affiliations": [
        "Haematology and Hemotherapy Department, Ramón y Cajal University Hospital, IRYCIS, Madrid, Spain"
      ],
      "name": "Javier López Jiménez"
    },
    {
      "affiliations": [
        "Department of Pharmacology, Pharmacognosy and Botany, Universidad Complutense de Madrid, Madrid, Spain"
      ],
      "name": "Sagrario Martín-Aragón"
    },
    {
      "affiliations": [
        "Department of Hospital Pharmacy, Ramón y Cajal University Hospital, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain"
      ],
      "name": "Ana María Álvarez-Díaz"
    }
  ],
  "title": "Comprehensive PHARmaceutical care programme in patients undergoing ALLOgeneic haematopoietic stem cell transplantation (PHARALLO): protocol for a prospective interventional study with a historical control group",
  "uid": "7c8ceaf1-fd49-59b1-b1ce-59f3f993dd32"
}