{
  "abstract": "The 2024 Infectious Diseases Society of America (IDSA) guidance on the treatment of antimicrobial-resistant Gram-negative infections represents an effort to provide practice suggestions in the light of limited but rapidly evolving literature.1 Many of the suggestions stem from low-quality evidence or expert opinion extrapolated from non-clinical, in vitro data. One suggestion warranting further examination is the universal adoption of high-dose meropenem (ie, 2 g intravenously (IV) every 8 hours) as an extended infusion (EI) over 3 hours for all infections other than uncomplicated cystitis. While the guidance body text acknowledges patient-specific considerations, summary tables are frequently extracted and used in isolation, shaping institutional protocols and antimicrobial stewardship policies without the accompanying nuance. This illustrates a recurring theme and important flaw in the creation of guideline, guidance and other best practice documents: the absence of an agreed upon standard of evidence that should be met prior to making sweeping, practice-changing suggestions or recommendations.",
  "authors": [
    {
      "affiliations": [
        "Division of Infectious Diseases, The University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA",
        "Department of Pharmacy, The University of New Mexico Hospital, Albuquerque, New Mexico, USA"
      ],
      "name": "M. Gabriela Cabanilla"
    },
    {
      "affiliations": [
        "Department of Pharmacy, King Abdulaziz Medical City - Jeddah, Jeddah, Saudi Arabia"
      ],
      "name": "Bassam Ghanem"
    },
    {
      "affiliations": [
        "Clinic for Infectious and Tropical Diseases “Prof. dr Kosta Todorović”, University Clinical Center of Serbia, Belgrade, Serbia",
        "Medical Faculty, University of Belgrade, Belgrade, Serbia"
      ],
      "name": "Boris Jegorović"
    },
    {
      "affiliations": [
        "Division of Infectious Diseases, Department of Medicine, McGill University, Montreal, Quebec, Canada"
      ],
      "name": "Todd C Lee"
    },
    {
      "affiliations": [
        "Department of Pharmacy Practice and Administration, Palm Beach Atlantic University - Lloyd L Gregory School of Pharmacy, West Palm Beach, Florida, USA"
      ],
      "name": "Elias B Chahine"
    },
    {
      "affiliations": [
        "Department of Pharmacology & Toxicology, Medical College of Georgia, Augusta, Georgia, USA"
      ],
      "name": "Daniel T Anderson"
    },
    {
      "affiliations": [
        "Division of Pharmacy Practice, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brookville, New York, USA",
        "Department of Pharmacy, Staten Island University Hospital, New York, New York, USA"
      ],
      "name": "Nardine Karam Salgado"
    },
    {
      "affiliations": [
        "Department of Pharmacy, Wellstar MCG Health, Augusta, Georgia, USA"
      ],
      "name": "Joshua Eudy"
    },
    {
      "affiliations": [
        "Division of Infectious Diseases, Weill Cornell Medicine, New York, New York, USA"
      ],
      "name": "Harjot K Singh"
    },
    {
      "affiliations": [
        "Infectious Diseases and Immunology Laboratory, Abha Maternity and Children Hospital (AMPH), Aseer Central Hospital, Abha, Saudi Arabia"
      ],
      "name": "Ahmed A Muyidi"
    },
    {
      "affiliations": [
        "Department of Medicine and Surgery, LUM \"Giuseppe Degennaro\" University, Casamassima, Bari, Italy"
      ],
      "name": "Roberta Astorri"
    },
    {
      "affiliations": [
        "Section of Infectious Diseases, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy"
      ],
      "name": "Alberto E Maraolo"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Complejo Asistencial de Ávila, Ávila‎, Spain"
      ],
      "name": "Ana Cristina Antolí Royo"
    },
    {
      "affiliations": [
        "Division of Infectious Diseases, University of Illinois Chicago, Chicago, Illinois, USA"
      ],
      "name": "Alfredo J Mena Lora"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Emergency Department, Hospital da Luz Lisboa, Lisbon, Portugal",
        "Catholic University of Portugal Católica Medical School, Lisbon, Portugal"
      ],
      "name": "Bernardo V Pimentel"
    },
    {
      "affiliations": [
        "Hospital Administration, Los Angeles General Medical Center, Los Angeles, California, USA",
        "Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"
      ],
      "name": "Brad Spellberg"
    }
  ],
  "title": "Universal high-dose meropenem for antimicrobial-resistant Gram-negative infections: evidence or overreach?",
  "uid": "2abc3317-ad74-5319-8946-e60c61586107"
}