{
  "abstract": "Objectives Database-assisted screening may help detect the risks of drug interactions, but less than 10% of flagged interactions have clinical manifestations, potentially leading to alert fatigue among healthcare providers. To address this issue, this study aimed to develop a concise framework to support the management of database-indicated interaction risks.Methods A grounded theory approach was used to design, evaluate and develop the framework. Participants included healthcare professionals and laypersons with experience using narrow therapeutic index medications, as well as individuals recommended by them. Two focus group discussions were conducted (N 1=6 and N2=5), each lasting approximately 2 hours and following the same agenda. In one case, a follow-up one-on-one interview was held because the participant indicated further insights at the end of the session.Results Participants identified key decision-making questions for the framework, including the evidence base for interacting drugs, severity and documentation level of the interaction, availability of safer alternatives, and the presence of confounding factors. The framework was considered useful and, following refinement, potentially suitable for clinical implementation. A key insight was that integration into healthcare curricula is essential for achieving long-term impact. Overall, the proposed tool may assist in managing interaction risks in diverse clinical scenarios and reduce alert fatigue among healthcare professionals.Conclusion Although further clinical validation is needed, the framework provides a foundation for improving the management of database-detected drug interactions.",
  "authors": [
    {
      "affiliations": [
        "University Pharmacy Department of Pharmacy Administration, Semmelweis University, Budapest, Hungary"
      ],
      "name": "Dénes Kleiner"
    },
    {
      "affiliations": [
        "University Pharmacy Department of Pharmacy Administration, Semmelweis University, Budapest, Hungary"
      ],
      "name": "Faraz Haghverdi"
    },
    {
      "affiliations": [
        "University Pharmacy Department of Pharmacy Administration, Semmelweis University, Budapest, Hungary"
      ],
      "name": "Orsolya Szépe"
    },
    {
      "affiliations": [
        "University Pharmacy Department of Pharmacy Administration, Semmelweis University, Budapest, Hungary",
        "Centre for Translational Medicine, Semmelweis University, Budapest, Hungary"
      ],
      "name": "István László Horváth"
    },
    {
      "affiliations": [
        "University Pharmacy Department of Pharmacy Administration, Semmelweis University, Budapest, Hungary"
      ],
      "name": "Szilvia Sebők"
    },
    {
      "affiliations": [
        "Centre for Translational Medicine, Semmelweis University, Budapest, Hungary",
        "Institute of Clinical Pharmacy, University of Szeged, Szeged, Hungary",
        "Institute for Translational Medicine, University of Pécs, Pécs, Hungary"
      ],
      "name": "Dezső Csupor"
    },
    {
      "affiliations": [
        "Neurocognitive Research Center, Nyírő Gyula National Institute of Psychiatry and Addictology, Budapest, Hungary",
        "Department of Anatomy, Histology and Embryology, Semmelweis University , Budapest, Hungary"
      ],
      "name": "András Horváth"
    },
    {
      "affiliations": [
        "Bajcsy-Zsilinszky Hospital and Clinic, Budapest, Hungary"
      ],
      "name": "Artúr György Balogh"
    },
    {
      "affiliations": [
        "Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary"
      ],
      "name": "Katalin Monostory"
    },
    {
      "affiliations": [
        "Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, Budapest, Hungary"
      ],
      "name": "László Kóbori"
    },
    {
      "affiliations": [
        "Department of Internal Medicine and Oncology (Division of Oncology), Semmelweis University, Budapest, Hungary"
      ],
      "name": "Máté Balázs"
    },
    {
      "affiliations": [
        "Department of Internal Medicine and Oncology (Division of Oncology), Semmelweis University, Budapest, Hungary"
      ],
      "name": "Magdolna Dank"
    },
    {
      "affiliations": [
        "Department of Family Medicine, Semmelweis University, Budapest, Hungary"
      ],
      "name": "Csaba Mihály Móczár"
    },
    {
      "affiliations": [
        "Department of Family Medicine, Semmelweis University, Budapest, Hungary"
      ],
      "name": "Ádám Becze"
    },
    {
      "affiliations": [
        "Department of Pharmacy, Peterfy Hospital and Clinic, Budapest, Hungary"
      ],
      "name": "András Süle"
    },
    {
      "affiliations": [
        "University Pharmacy Department of Pharmacy Administration, Semmelweis University, Budapest, Hungary"
      ],
      "name": "Romána Zelkó"
    }
  ],
  "title": "How to manage the overwhelming amount of database-detected interactions? A focus group meeting study on the management of database-detected risks of drug interactions",
  "uid": "7b4fe715-f257-5800-9c53-2b62a9917163"
}