{
  "abstract": "This case describes the individualised pharmacological management of a 2-month-old infant with genetically confirmed type I hypertriglyceridemia due to lipoprotein lipase (LPL) deficiency. After the failure of conventional treatment and contraindication to plasmapheresis, intravenous insulin therapy was initiated, followed by subcutaneous insulin and omega-3 fatty acid adjustment. The hospital pharmacist played a key role in selecting off-label treatments, adapting pharmaceutical forms for paediatric use and performing therapeutic reconciliation. The approach was effective and safe, achieving triglyceride levels below 1000 mg/dL and clinical stability. This report contributes practical evidence on alternative treatment strategies for a rare disease with limited therapeutic options in paediatrics, highlighting the importance of a multidisciplinary approach and pharmaceutical care.",
  "authors": [
    {
      "affiliations": [
        "Pharmacy, Hospital Infantil Universitario Niño Jesús, Madrid, Spain"
      ],
      "name": "Alejandra Merino Pardo"
    },
    {
      "affiliations": [
        "Pharmacy, Hospital Infantil Universitario Niño Jesús, Madrid, Spain"
      ],
      "name": "Marta Echávarri De Miguel"
    },
    {
      "affiliations": [
        "Pharmacy, Hospital Infantil Universitario Niño Jesús, Madrid, Spain"
      ],
      "name": "Esther Algarra Sánchez"
    },
    {
      "affiliations": [
        "Gastroenterology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain"
      ],
      "name": "Elvira Cañedo Villarroya"
    },
    {
      "affiliations": [
        "Pharmacy, Hospital Infantil Universitario Niño Jesús, Madrid, Spain"
      ],
      "name": "Margarita Cuervas Mons Vendrell"
    }
  ],
  "title": "Severe hypertriglyceridemia due to lipoprotein lipase deficiency in an infant: pharmacological and nutritional approach",
  "uid": "278a941d-b75a-5049-b78b-f2877e4adc14"
}