{
  "abstract": "Background and Importance Venous thromboembolism (VTE) is a preventable in-hospital cause of morbidity and mortality. Evaluating adherence to thromboprophylaxis protocols is essential for patient safety.Aim and Objectives To evaluate adherence to the VTE prophylaxis protocol in medical inpatients.Material and Methods A cross-sectional, descriptive, retrospective study was conducted in a 450-bed university hospital. Three-point prevalence assessments were conducted between November 2024 and January 2025 in medical wards. Patients in ICU, semi-critical, psychiatry, or same-day discharged were excluded. Clinical records were reviewed to collect demographic and anthropometric data, renal function, department and admission date, baseline treatment, and thromboprophylaxis (drug, regimen, and start date). Prescriptions were assessed for adequacy according to the institutional protocol. In patients not receiving prophylaxis, thrombotic risk was calculated using the Padua scale, and contraindications for pharmacological thromboprophylaxis were reviewed. Complex cases were discussed by a multidisciplinary team.Results A total of 100 patients were included (59% male, mean age 69 ± 15 years). The main admission services were: internal medicine (32%); onco-haematology (15%); infectious diseases (14%); neurology (11%); digestive (10%); cardiology (9%), and pulmonology (9%). Thirty-one percent received chronic oral anticoagulation: 26 continued treatment on admission, 4 discontinued it for clinical reasons, and one was not prescribed without justification. One patient started anticoagulation therapy during hospitalisation for pulmonary thromboembolism. Sixty-eight patients were candidates for VTE prophylaxis: 24/68 (35.3%) received tromboprophylaxis, 11 of whom initiated it on the admission day. Prescriptions were appropriate in 15 cases and inadequate in 9, mainly (6/9) due to suboptimal enoxaparin dosing in relation to their weight or body mass index. Among the 44 patients without prophylaxis, 29/44 (65.9%) had a justified omission: 16 with Padua scale values<4 and 13 with contraindications to thromboprophylaxis (5 with high bleeding risk procedures, 4 with thrombocytopenia or risk thereof and 4 other reasons). Thromboprophylaxis was omitted without clinical justification in 15 of 44 indicated cases (34.1%). Overall, adherence to the thromboprophylaxis protocol was 64.7 %.Conclusion and Relevance Adherence to the institutional thromboprophylaxis protocol was moderate. An electronic calculation tool is being developed to enhance current thromboprophylaxis practices and optimise dosing based on patient parameters. The small eligible population, mainly due to baseline anticoagulation, was the principal study limitation.Conflict of Interest No conflict of interest",
  "authors": [
    {
      "affiliations": [
        "Hospital Universitari Mútua Terrassa, Pharmacy, Terrassa, Spain"
      ],
      "name": "B Tenas"
    },
    {
      "affiliations": [
        "Hospital Universitari Mútua Terrassa, Pharmacy, Terrassa, Spain"
      ],
      "name": "M Mensa"
    },
    {
      "affiliations": [
        "Hospital Universitari Mútua Terrassa, Pharmacy, Terrassa, Spain"
      ],
      "name": "F Salazar"
    },
    {
      "affiliations": [
        "Hospital Universitari Mútua Terrassa, Pharmacy, Terrassa, Spain"
      ],
      "name": "I Vázquez"
    },
    {
      "affiliations": [
        "Hospital Universitari Mútua Terrassa, Pharmacy, Terrassa, Spain"
      ],
      "name": "C García"
    },
    {
      "affiliations": [
        "Hospital Universitari Mútua Terrassa, Pharmacy, Terrassa, Spain"
      ],
      "name": "V Insense"
    },
    {
      "affiliations": [
        "Hospital Universitari Mútua Terrassa, Hemostasis Unit, Terrassa, Spain"
      ],
      "name": "M López De La Fuente"
    },
    {
      "affiliations": [
        "Hospital Universitari Mútua Terrassa, Hemostasis Unit, Terrassa, Spain"
      ],
      "name": "B Barreiro López"
    },
    {
      "affiliations": [
        "Hospital Universitari Mútua Terrassa, Pharmacy, Terrassa, Spain"
      ],
      "name": "J Nicolás"
    }
  ],
  "title": "5PSQ-058 Evaluation of adherence to the venous thromboembolism prophylaxis protocol in medical inpatients",
  "uid": "f2e13a2f-b8f2-5239-9d62-009b116cdff3"
}