{
  "abstract": "Background and Importance Anticancer drugs involve complex regimens and narrow therapeutic margins, making it susceptible to drug related problems (DRP). Pharmacists play a critical role in detecting and preventing DRPs. Earlier at the Universitair Ziekenhuis Brussel (UZ Brussel) in 2023 a validation was developed to detect DRPs and support pharmacist interventions (PIs) in parenteral chemotherapy.Aim and Objectives This study aims to evaluate the potential clinical, economic and organisational impact of the validation tool for parenteral chemotherapy as part of a quality improvement programme.Material and Methods A retrospective evaluation study of a quality improvement programme was conducted at the chemotherapy preparation unit (CPU) of UZ Brussel for all patients receiving parenteral chemotherapy. Parenteral chemotherapy prescriptions were screened for DRPs and with the resulting PIs were recorded in a register using the Be-CLIPSS classification system. This register was retrospectively reviewed by an expert panel, which assessed the clinical, economic, and organisational impact of each PI using the CLEO tool.Results A total of 10.696 parenteral chemotherapy prescriptions were analysed with a significant increase in DRP detection (0.3% vs 1.4%; p <0.001). More clinically significant PIs (19.48%) were detected in the tool supported period. A notable economic benefit of 105.652,99€ was observed in the tool supported period and the validation time for parenteral chemotherapy prescriptions decreased significantly, with a median time reduction from 16:11 (07:16-33:45) minutes to 14:50 (6:00-33:00) minutes (p < 0.001).Conclusion and Relevance The validation tool is associated with a positive clinical, economic and organisational impact. The tool significantly improved the detection of drug-related problems and a reduction of validation time.Conflict of Interest No conflict of interest",
  "authors": [
    {
      "affiliations": [
        "UZ Brussel, Hospital Pharmacy, 1090- Jette, Belgium"
      ],
      "name": "J Vanfleteren"
    }
  ],
  "title": "4CPS-005 Clinical, economic and organisational impact of a validation tool on parenteral chemotherapy",
  "uid": "e8ba31d1-74b7-5eaf-81e8-104df0eff6a6"
}