{
  "abstract": "Background and Importance Drug preparations under early access authorisation (EAA) and compassionate use authorisation (CUA) is a key activity of our pharmacy. At the same time we are trying to implement the socio-economic management (SEAM) in our pharmacy. 1 According to this method we need to estimate the hidden costs (HD). HD is the cost of regulation of dysfunctions. They are divided into different types of regulation, including overconsumption and overtime.We aimed to estimate the HD in euros (€) of preparations under EAA and CUA regarding overtime and overconsumption.1 Aim and Objectives Estimate the HD of our preparations under EAA and CUA over an 18-month period.Material and Methods First, the cost of these preparations was worked out according to the number of vials and their unit price.This amount was corrected by hourly contribution to value-added on variable costs (HCVAVC), which is the real average cost of 1 hour of human activity within a company (1) to include the human time to prepare.Finally, we calculated the HC of non-compliance for our preparations. They include overconsumption and overtime. Knowing our rejection rate (RR) for preparations (which we assumed to be constant in 2025), as well as the average number of vials consumed for a preparation according to our records and the average unit price, we were able to calculate these HC.Results We made 4291 preparations between January 24 and June 2025.Our HCVAVC was 47€ in 2024. Total time for a preparation was 30 minutes.Our RR was 2%, so 85 preparations have to be redone. Three vials were used per preparation and average unit price was 2302€, that was 587 000€ of overconsumption and 1998 € of overtime.In total, the HD represented 588 998€.Conclusion and Relevance Based on the SEAM we found that the HD represents almost 600 000€ mainly due to overconsumption.It is essential to structure the training and deepen it; the better trained the hospital’s technicians are, the less non-compliance there will be. Plus using more preparation robots is essential to reduce non-compliance and preparation times.References and/or Acknowledgements 1. Cappelletti L, Savall H, Zardet V. Socio-economic approach to management: science-based consulting for sustainability. Springer Nature Switzerland; 2024.Conflict of Interest No conflict of interest",
  "authors": [
    {
      "affiliations": [
        "Gustave Roussy, Val De Marne, Villejuif, France"
      ],
      "name": "E Cosme"
    },
    {
      "affiliations": [
        "Gustave Roussy, Val De Marne, Villejuif, France"
      ],
      "name": "A Rieutord"
    }
  ],
  "title": "1ISG-003 Estimation of the hidden costs of drug preparations in early access authorisation and compassionate use authorisation over 18 months",
  "uid": "e6297679-d16b-58ff-933f-499620ab47a6"
}