{
  "abstract": "Background and Importance Haemodialysis patients are at high risk of malnutrition, linked to worse clinical outcomes and increased morbidity and mortality. ESPEN and KDOQI guidelines recommend intradialytic parenteral nutrition (IDPN) for patients intolerant to oral or enteral diet and not meeting nutritional requirements. Nevertheless, evidence regarding the effectiveness of IDPN remains limited and is mostly derived from small cohorts.Aim and Objectives To evaluate the impact of IDPN on nutritional and biochemical parameters at baseline, 3 months, and 6 months.Material and Methods Observational, retrospective, multidisciplinary study conducted in a tertiary hospital including adult patients receiving IDPN for >6months (2021-January 2025)Data collected: demographics and anthropometric parameters, Charlson Comorbidity Index (CCI), calories and protein intake at baseline, and nutritional and biochemical parameters: glucose, total protein (TP), serum albumin (Alb), C-reactive protein (CRP), CRP/Alb ratio, creatinine, glomerular filtration rate (GFR), triglycerides, cholesterol, and urea.Qualitative variables were expressed as absolute and relative frequencies, and quantitative variables as median and interquartile range. The Wilcoxon signed-rank test was used for comparisons between related samples.Results Seven patients were included: 4 (57.1%) female; median age of 67 years (63-65). The median weight was 54.6kg (45.5-62.3), BMI 19.3kg/m 2 (16.7-22.9) and CCI 5 (5-8). Patients received IDPN three times per week, with a median of 16.5kcal/kg/day (14.6-18.8) and 1.2g of protein/kg/day (1-1.3).Serum albumin increased during follow-up, reaching statistical significance between months 3 and 6 (p=0.043). BMI, TP, and cholesterol increased, while CRP and CRP/Alb ratio decreased, indicating favourable but non-significant trends.Other parameters remained stable without significant changes.Abstract 4CPS-048 Table 1 Parameter Month 0 Month 3 Month 6 P (0- 3) P (0- 6) P (3-6) Weight (kg) 54.6 (45.5-62.3) 50.5 (43-60) 57.3 (46-68.8) 0.686 0.345 0.144 BMI (kg/m2) 19.3 (16.7-22.9) 17.0 (16-25.5) 20.8 (16.9-26.5) 0.686 0.345 0.144 Glucose (mg/dL) 92 (86-121) 128 (85-181) 136 (119-347) 0.345 0.144 0.225 TP (g/L) 50.4 (46.5-74) 53.8 (52.5-55) 70 (53.9-86.1) 0.180 1.000 1.000 Albumin (g/dL) 2.74 (2.56-3.64) 3.30 (3.21-3.37) 3.41 (3.39-3.65) 0.237 0.116 0.043 CRP (mg/L) 26.3 (4.9-44.8) 15.5 (5.3-117.5) 6 (2.5-279) 0.500 1.000 0.655 CRP/Alb ratio 8.41 (1.35-18.9) 4.13 (1.5-39.9) 1.75 (0.7-82.2) 0.500 1.000 0.655 Urea (mg/dL) 92 (60-174) 105 (75-153) 101.8 (63-107) 0.753 0.686 0.500 Creatinine (mg/dL) 6.38 (3.8-11.5) 6.06 (5.7-9.4) 5.59 (1.6-7.1) 0.345 0.593 0.225 GFR (ml/min) 8.5 (6-11.5) 6.0 (4-12) 7 (5-13) 0.092 0.593 1.000 Triglycerides (mg/dL) 117 (86-143) 116 (98-213) 115 (97-574) 0.465 0.465 0.225 Cholesterol (mg/dL) 115 (84-133) 143.5 (83-265) 175 (115-245) 0.225 0.068 0.500 Conclusion and Relevance Consistent with previous evidence and limited by a small cohort, our findings suggest progressive nutritional improvement.However, further studies with larger cohorts are warranted to confirm these resultsConflict of Interest No conflict of interest",
  "authors": [
    {
      "affiliations": [
        "Hospital Germans Trias I Pujol, Pharmacy, Badalona, Spain"
      ],
      "name": "R Gil Bardaji"
    },
    {
      "affiliations": [
        "Hospital Germans Trias I Pujol, Pharmacy, Badalona, Spain"
      ],
      "name": "J Miedes-Aliaga"
    },
    {
      "affiliations": [
        "Hospital Germans Trias I Pujol, Endocrinology, Badalona, Spain"
      ],
      "name": "C Joaquín Ortiz"
    },
    {
      "affiliations": [
        "Hospital Germans Trias I Pujol, Endocrinology, Badalona, Spain"
      ],
      "name": "L Ferrer Estopiñan"
    },
    {
      "affiliations": [
        "Hospital Germans Trias I Pujol, Endocrinology, Badalona, Spain"
      ],
      "name": "AE Ramos Rodas"
    },
    {
      "affiliations": [
        "Hospital Germans Trias I Pujol, Pharmacy, Badalona, Spain"
      ],
      "name": "C Codina-Jimenez"
    },
    {
      "affiliations": [
        "Hospital Germans Trias I Pujol, Endocrinology, Badalona, Spain"
      ],
      "name": "C Puente De La Vega Gonzales"
    },
    {
      "affiliations": [
        "Hospital Germans Trias I Pujol, Pharmacy, Badalona, Spain"
      ],
      "name": "C Rodríguez-González"
    },
    {
      "affiliations": [
        "Hospital Germans Trias I Pujol, Pharmacy, Badalona, Spain"
      ],
      "name": "S Garcia-Xipell"
    },
    {
      "affiliations": [
        "Hospital Germans Trias I Pujol, Pharmacy, Badalona, Spain"
      ],
      "name": "M Coll-Vinent Ollé"
    },
    {
      "affiliations": [
        "Hospital Germans Trias I Pujol, Pharmacy, Badalona, Spain"
      ],
      "name": "M Alvarez-Martins"
    }
  ],
  "title": "4CPS-048 Can intradialytic parenteral nutrition improve nutritional parameters in haemodialysis patients?",
  "uid": "e03df48a-acde-5be4-874b-213332fa9b00"
}