{
  "abstract": "Background and Importance Daptomycin is a cyclic lipopeptide antibiotic widely used for treating serious gram-positive bacterial infections. While generally well-tolerated, evidence 1 suggests potential pulmonary toxicity, including eosinophilic pneumonia, a rare but serious adverse reaction characterised by eosinophil accumulation in lung tissue. Eosinophilic pneumonia represents a significant clinical concern due to its potential severity and the need for prompt recognition and management.Aim and Objectives To assess the association between daptomycin use and eosinophilic pneumonia through disproportionality analysis of real-world pharmacovigilance data.Material and Methods The analysis was performed by extracting suspected adverse drug reaction cases from the Food and Drug Administration Adverse Event Reporting System (FAERS) Public Dashboard. Data were extracted and filtered to identify reports of eosinophilic pneumonia (coded according to Medical Dictionary for Regulatory Activities v27.0) in association with daptomycin. The disproportionality analysis was conducted using IBM SPSS Modeler 15.0. The evaluated time period spanned approximately 10 years, from January 2015 to June 2025. Proportional Reporting Ratio (PRR), Reporting Odds Ratio (ROR), Chi-squared statistics, and corresponding 95% confidence intervals (CI) were calculated. The criteria defined by Evans 2 were applied to assess signal detection: PRR>2, Chi-squared>4, and at least 3 cases (n>2).Results The disproportionality analysis demonstrated a statistically significant association between daptomycin and eosinophilic pneumonia. The calculated disproportionality measures were PRR 830.9 (95% CI: 731.575-943.611), ROR 907.5 (95% CI: 791.75-1040.281), and Chi-squared 180895.4.According to the criteria of Evans this combination of drug and adverse event is considered ‘likely an adverse reaction’.Conclusion and Relevance According to our analysis, daptomycin is probably associated with eosinophilic pneumonia. These findings support the need for pulmonary monitoring during therapy and underscore the key role of hospital pharmacists in detecting rare adverse reactions and enhancing patient safety through active pharmacovigilance.References and/or Acknowledgements 1. Nota Informativa Importante su Daptomicina (Cubicin) (21/01/2011) - AIFA Agenzia Italiana del Farmaco:https://www.aifa.gov.it/-/nota-informativa-importante-su-daptomicina-cubicin-21-01-2011-. Last accessed:September 20252. Evans SJ, et al. Use of proportional reporting ratios (PRRs) for signal generation from spontaneous adverse drug reaction reports. Pharmacoepidemiol Drug Saf. 2001;10(6):483–486.doi: 10.1002/pds.677.Conflict of Interest No conflict of interest",
  "authors": [
    {
      "affiliations": [
        "Azienda Ospedaliero Universitaria- Città Della Salute E Della Scienza Di Torino- Turin-Piedmont-Italy, Hospital Pharmacy, Turin, Italy"
      ],
      "name": "E Castellana"
    },
    {
      "affiliations": [
        "Azienda Ospedaliero Universitaria- Città Della Salute E Della Scienza Di Torino- Turin-Piedmont-Italy, Hospital Pharmacy, Turin, Italy"
      ],
      "name": "D Cestino"
    },
    {
      "affiliations": [
        "Azienda Ospedaliero Universitaria- Città Della Salute E Della Scienza Di Torino- Turin-Piedmont-Italy, Hospital Pharmacy, Turin, Italy"
      ],
      "name": "A Tarozzo"
    },
    {
      "affiliations": [
        "Azienda Ospedaliero Universitaria- Città Della Salute E Della Scienza Di Torino- Turin-Piedmont-Italy, Hospital Pharmacy, Turin, Italy"
      ],
      "name": "R Viglianti"
    },
    {
      "affiliations": [
        "Azienda Ospedaliero Universitaria- Città Della Salute E Della Scienza Di Torino- Turin-Piedmont-Italy, Hospital Pharmacy, Turin, Italy"
      ],
      "name": "L Bagnasco"
    },
    {
      "affiliations": [
        "Azienda Ospedaliero Universitaria- Città Della Salute E Della Scienza Di Torino- Turin-Piedmont-Italy, Hospital Pharmacy, Turin, Italy"
      ],
      "name": "C Molon"
    },
    {
      "affiliations": [
        "Azienda Ospedaliero Universitaria- Città Della Salute E Della Scienza Di Torino- Turin-Piedmont-Italy, Hospital Pharmacy, Turin, Italy"
      ],
      "name": "MR Chiappetta"
    }
  ],
  "title": "5PSQ-042 Eosinophilic pneumonia associated with daptomycin: a disproportionality analysis from ten years of pharmacovigilance data",
  "uid": "dbb57e49-10e3-5f5c-81d2-bfd3e552113e"
}