{
  "abstract": "Background and Importance In October 2024, a semi-automated process was implemented in nursing homes (NH) to detect and reduce potentially inappropriate prescriptions (PIPs) that exceed the maximum recommended dose: omeprazole, esomeprazole and rabeprazole ≥ 40 mg/day, pantoprazole ≥ 80 mg/day, lansoprazole ≥ 60 mg/day (PPIs); zolpidem > 5 mg/day (ZLP); acetylsalicylic acid > 100mg/day (AAS); citalopram > 20 mg/day, escitalopram > 10 mg/day (SSRIs); iron > 200mg/day (Fe). After the pharmaceutical intervention (PI), PIPs were reduced by 66.5%. Long-term follow-up is crucial to assess the intervention.Aim and Objectives To analyse the number of PIPs exceeding maximum doses nine months after the PI, assess changes within each PIP group, and identify the reasons for those changes.Material and Methods Automatic data extraction was used to analyse the intervened population.Reasons for changes in each PIP group were examined.Alternative drugs were identified for each PIP group:a. PPIs: antacidsb. ZLP: hypnotics/anxiolyticsc. AAS: antiplateletsd. SSRIs: antidepressantse. Iron: anti–anaemic agentsResults After the PI in October 2024, 158 patients had PIPs; nine months later, 123 patients had PIPs. During this period, 35 patients died.Abstract 5PSQ-048 Table 1Results of PIP number PPIs ZLP AAS SSRIs Fe Number of PIPs (October 2024)(n=158) 20 20 1 8 5 Number of PIPs (July 2025) (n=123) 17 14 1 8 2 Reasons for changes in each PIP group:PPIs: 5 deaths, 2 restarted for gastrointestinal symptomsZLP: 7 deaths, 1 restarted for unknown reasonsAAS: no changes observedSSRIs: no changes observedFe: 4 deaths, 1 restarted for unknown reasonsAlternative treatments:ZLP: diazepam (n=1)SSRI: vortioxetine (n=1) and paroxetine (n=1)Conclusion and Relevance The reduction in PIPs exceeding maximum doses was largely maintained nine months after the PI, with minimal use of alternative treatments.This approach supports safer prescribing and represents a practical tool for optimising pharmacotherapy in NH patients.Conflict of Interest No conflict of interest",
  "authors": [
    {
      "affiliations": [
        "Osakidetza- Donostia University Hospital, Hospital Pharmacy, Basque Country, Spain"
      ],
      "name": "I Zipitria Sinde"
    },
    {
      "affiliations": [
        "Osakidetza- Donostia University Hospital, Hospital Pharmacy, Basque Country, Spain"
      ],
      "name": "A Ros Olaso"
    },
    {
      "affiliations": [
        "Osakidetza- Donostia University Hospital, Hospital Pharmacy, Basque Country, Spain"
      ],
      "name": "A Martiarena Ayestaran"
    },
    {
      "affiliations": [
        "Osakidetza- Donostia University Hospital, Hospital Pharmacy, Basque Country, Spain"
      ],
      "name": "I Barral Juez"
    },
    {
      "affiliations": [
        "Osakidetza- Donostia University Hospital, Hospital Pharmacy, Basque Country, Spain"
      ],
      "name": "I Sánchez Monasterio"
    },
    {
      "affiliations": [
        "Osakidetza- Donostia University Hospital, Hospital Pharmacy, Basque Country, Spain"
      ],
      "name": "M Salegi Ansa"
    },
    {
      "affiliations": [
        "Osakidetza- Donostia University Hospital, Hospital Pharmacy, Basque Country, Spain"
      ],
      "name": "N Ugartetxea Arakistain"
    },
    {
      "affiliations": [
        "Osakidetza- Donostia University Hospital, Hospital Pharmacy, Basque Country, Spain"
      ],
      "name": "L Murua Etxarri"
    },
    {
      "affiliations": [
        "Osakidetza- Donostia University Hospital, Hospital Pharmacy, Basque Country, Spain"
      ],
      "name": "L Simon Castelruiz"
    },
    {
      "affiliations": [
        "Osakidetza- Donostia University Hospital, Hospital Pharmacy, Basque Country, Spain"
      ],
      "name": "C Saiz Martinez"
    },
    {
      "affiliations": [
        "Osakidetza- Donostia University Hospital, Hospital Pharmacy, Basque Country, Spain"
      ],
      "name": "A Latasa Berasategui"
    }
  ],
  "title": "5PSQ-048 9-month outcomes of a pharmaceutical intervention to reduce exceeding maximum dose prescriptions in elderly people",
  "uid": "d7149329-cae5-5397-949c-b3522170ef7a"
}