{
  "abstract": "Background and Importance Suppurative hidradenitis (SH) is a chronic, immune-mediated, systemic, progressive, and suppurative inflammatory skin disease.SH impacts quality of life socially and sexually due to odour and disfigurement, professionally by increasing the risk of social exclusion, and psychologically as it is associated with anxiety and depression.Aim and Objectives To analyse the impact of SH on the quality of life of patients undergoing biological therapy. We also evaluated mental health status and characterised the sociodemographic profile through validated questionnaires.Material and Methods Prospective, observational, single-centre study in SH adult patients receiving biological treatment (adalimumab, secukinumab or bimekizumab) at a general hospital (March-June 2025).Those unable to complete questionnaires, unable to understand Spanish or includedin clinical trials were excluded.Hospital health system’s digital medical program, Pharmacy software, excel and SPSS were used.Patients who provided informed consent, recieved an information sheet, the Hospital Anxiety and Depression Scale (HADS), and the HS-specific quality of life questionnaire (HSQoL-24).Results Abstract 5PSQ-037 Table 1Sociodemographic profile n Median age Adalimumab Secukinumab Median disease duration (year) Median treatment Duration (month) Hurley stage II Hurley stage III 19 45 (25.00-58.00) 14 5 5.5 (3.25-8.75) 17 (7.00-36.00) 6 11 Disease progression was assessed using severity index for SH and CRP, showing reductions with biological treatment (p<0.05).The most prevalent risk factors were smoking (52.63%) and overweight/obesity (63.16%). Comorbidities such as acne and anxiety were also present.HSQoL-24 results showed severe impact in the psychosocial (57.89%) and relational (63.16%) domains. The occupational domain was more evenly distributed, with 31.58% reporting no impact. Most patients did not report significant impact in economic (47.37%), clinical (52.63%), or personal (42.10%) domains. Overall, 52.63% showed severe quality of life impairment.Subgroup analysis revealed differences in smokers regarding depression, occupational impact, and overall impact, and in patients with anxiety regarding psychosocial and overall impact (p<0.05).Abstract 5PSQ-037 Table 2Mental health Hads Severity Patients ANSIETY Normal 11 Mild 5 Moderate/severe 3 DEPRESSION Normal 14 Mild 4 Moderate/severe 1 Conclusion and Relevance Over half of the patients smoke and were overweight/obese.More than 50% of patients showed no signs of anxiety, and around 75% do not exhibit depressive patterns. However, mild and severe cases should be considered.SH severely affects patients‘ quality of life, being the most affected psychosocial and relational domains.Conflict of Interest No conflict of interest",
  "authors": [
    {
      "affiliations": [
        "Hospital Universitario De La Princesa, Pharmacy, Madrid, Spain"
      ],
      "name": "E Ramirez Herraiz"
    },
    {
      "affiliations": [
        "Hospital Universitario De La Princesa, Pharmacy, Madrid, Spain"
      ],
      "name": "M Pérez Abanades"
    },
    {
      "affiliations": [
        "Hospital Universitario De La Princesa, Pharmacy, Madrid, Spain"
      ],
      "name": "JM Serra López-Matencio"
    },
    {
      "affiliations": [
        "Hospital Universitario De La Princesa, Pharmacy, Madrid, Spain"
      ],
      "name": "A Calvo García"
    },
    {
      "affiliations": [
        "Hospital Universitario De La Princesa, Pharmacy, Madrid, Spain"
      ],
      "name": "A Collado Mohedano"
    },
    {
      "affiliations": [
        "Hospital Universitario De La Princesa, Pharmacy, Madrid, Spain"
      ],
      "name": "MD Ibáñez Zurriaga"
    },
    {
      "affiliations": [
        "Hospital Universitario De La Princesa, Pharmacy, Madrid, Spain"
      ],
      "name": "S Ruiz García"
    },
    {
      "affiliations": [
        "Hospital Universitario De La Princesa, Pharmacy, Madrid, Spain"
      ],
      "name": "A Álvarez Yuste"
    },
    {
      "affiliations": [
        "Hospital Universitario De La Princesa, Dermatology, Madrid, Spain"
      ],
      "name": "Y Delgado Jiménez"
    },
    {
      "affiliations": [
        "Hospital Universitario De La Princesa, Pharmacy, Madrid, Spain"
      ],
      "name": "A Aranguren Oyarzábal"
    }
  ],
  "title": "5PSQ-037 Quality of life in patients with suppurative hidradenitis",
  "uid": "cf3c1e6d-0e7a-5ee4-ae48-d3f87a8d37f2"
}