{
  "abstract": "Background and Importance At least one in four adults aged 65 or older experience a fall every year making falls a major health problem. Many factors can influence the risk of falling; among them is medication one of the adjustable factors. Identifying at-risk patients may prevent medication-related falls. We aimed to develop a list of FRIDs, which can be used as a screening tool to identify patients at risk of falling in Danish hospital.Aim and Objectives The study aimed to develop a screening tool of fall-risk-increasing drugs (FRIDs) to be used in medication reviews. A systematic review was conducted to identify FRIDs to be included in the tool.Material and Methods A systematic review was performed using PubMed and Embase including studies that developed, updated, or validated tools, models, or guidelines with FRIDs. To enhance applicability in Danish healthcare setting, only drugs used by ≥2.500 people in Denmark in 2024 were included. The identified drugs were scored (max 6 points) based on strength of evidence and fall-related side effects listed in Summary of Product Characteristics (SmPCs). Evidence was rated by frequency of mention of drugs, recency, and tool methodology. Drugs cited in ≥10 tools and supported by both predictive and consensus methods received the highest evidence score. The selection of fall-related side effects was based on those identified in previous studies that assessed fall risk through SmPCs.Results A total of 15 different tools, models, and recommendations assessing FRIDs were identified. The developed FRIDs screening tool contained 113 drugs. The majority affects the central nervous system (52.2%) or the cardiovascular system (27.4%). The FRIDs were grouped by their potential to cause falls. In total 53 (46.9%) drugs were classified as low risk FRIDs, 26 (23.0%) drugs as medium risk FRIDs and 34 (30.1%) drugs as high risk FRIDs.Conclusion and Relevance This developed FRIDs screening tool may help reduce medication-related falls. The screening tool should be tested in a Danish hospital. Potentially through integration in the electronic health record, where it could provide trigger alerts for patients prescribed multiple fall-risk-increasing drugs.Conflict of Interest No conflict of interest",
  "authors": [
    {
      "affiliations": [
        "The University Hospital Sønderjylland, The Hospital Pharmacy Research Unit, Aabenraa, Denmark"
      ],
      "name": "M Schlünsen"
    },
    {
      "affiliations": [
        "The University Hospital Sønderjylland, The Hospital Pharmacy Research Unit, Aabenraa, Denmark"
      ],
      "name": "S Julie"
    },
    {
      "affiliations": [
        "The University Hospital Sønderjylland, The Hospital Pharmacy Research Unit, Aabenraa, Denmark"
      ],
      "name": "JL Kjeldsen"
    }
  ],
  "title": "4CPS-328 Developing a screening toll for fall-risk-increasing drugs in a Danish hospital",
  "uid": "a3288f17-fd07-5402-8612-b24bce4510d9"
}