{
  "abstract": "Background and Importance Antibiotic consumption in both hospitals and community is well documented and represents a major challenge for appropriate use. In the interface area of these two sectors of care, hospital-origin prescription dispensed in community pharmacies (HPCP) remain underexplored, although they may represent a strategic lever for antimicrobial stewardship.Aim and Objectives The objective was to quantify, characterise, and compare for antibiotics (ATC J01), the contribution of HPCP to community consumption at both national and regional levels, with a specific focus on the three largest university hospitals in our country (UH): UH-1, UH-2, and UH-3.Material and Methods From 2021 to 2024, antibiotic dispensing data were extracted from national reimbursement databases. Consumption was converted into defined daily doses (DDD) following World Health Organization methodology and standardised per 1,000 inhabitants using annual regional population data for interregional comparison. For 2024, HPCP were analysed at national and regional levels (with a focus on the UHs). Finally, temporal trends (2021-2024) were assessed for selected antibiotic classes and molecules of clinical interest: quinolones, third-generation cephalosporins, amoxicillin, amoxicillin/clavulanic acid, macrolides and doxycycline.Results In 2024, HPCP accounted for 11.4% of the total DDD dispensed in community, corresponding to 64.5 million DDD. When adjusted for regional populations, HPCP varied considerably across regions (from 770 DDD/1,000 inhabitants to 1,268 DDD/1,000 inhabitants). In their respective regions, the share of prescriptions from the three largest UH reached 7.0% for UH-1 (612.2 DDD/1,000 inhabitants), 2.4% for UH-2 (230.2) and 2.8% for UH-3 (209.4). Nine out of 48 molecules belonging to the ATC J01 class accounted for 89.4% of the HPCP (57.6 million DDD). Overall, UH-1 followed trends similar to the other two UHs, but with higher consumption levels. Notable differences in prescribing patterns between hospital and community prescribers were observed, particularly for doxycycline (consumption increased at UH-1 while decreasing in its region) and for macrolides (in 2022, consumption increased at UH-2 while decreasing in its region).Conclusion and Relevance Hospital prescribers have a major role to play in rationalising outpatient antibiotic use. Disseminating these results to local (antimicrobial committees) and regional (regional antibiotic centres) bodies could foster a joint dynamic, aimed at supporting appropriate antibiotic prescribing and improving hospital-community coordination.Conflict of Interest No conflict of interest",
  "authors": [
    {
      "affiliations": [
        "General Agency of Equipment and Health Products Ageps – Assistance Publique-Hôpitaux De Paris Ap-Hp, Sepbu, Paris, France"
      ],
      "name": "PY De Reviers De Mauny"
    },
    {
      "affiliations": [
        "General Agency of Equipment and Health Products Ageps – Assistance Publique-Hôpitaux De Paris Ap-Hp, Sepbu, Paris, France"
      ],
      "name": "V Siorat"
    },
    {
      "affiliations": [
        "General Agency of Equipment and Health Products Ageps – Assistance Publique-Hôpitaux De Paris Ap-Hp, Sepbu, Paris, France",
        "Faculty of Pharmacy and Health Law Institute Inserm Umr S1145 Université Paris Cité, Law and Health Economics, Paris, France"
      ],
      "name": "M Tano"
    },
    {
      "affiliations": [
        "General Agency of Equipment and Health Products Ageps – Assistance Publique-Hôpitaux De Paris Ap-Hp, Sepbu, Paris, France"
      ],
      "name": "M Ribault"
    },
    {
      "affiliations": [
        "General Agency of Equipment and Health Products Ageps – Assistance Publique-Hôpitaux De Paris Ap-Hp, Sepbu, Paris, France",
        "Faculty of Pharmacy and Health Law Institute Inserm Umr S1145 Université Paris Cité, Law and Health Economics, Paris, France"
      ],
      "name": "P Paubel"
    },
    {
      "affiliations": [
        "General Agency of Equipment and Health Products Ageps – Assistance Publique-Hôpitaux De Paris Ap-Hp, Sepbu, Paris, France"
      ],
      "name": "O Parent De Curzon"
    },
    {
      "affiliations": [
        "General Agency of Equipment and Health Products Ageps – Assistance Publique-Hôpitaux De Paris Ap-Hp, Sepbu, Paris, France",
        "Faculty of Pharmacy and Health Law Institute Inserm Umr S1145 Université Paris Cité, Law and Health Economics, Paris, France"
      ],
      "name": "A Degrassat Theas"
    }
  ],
  "title": "5PSQ-150 Hospital-origin antibiotic prescriptions dispensed in community pharmacies: national/regional overview and comparison with community consumption dynamics",
  "uid": "99f2547a-fe03-57b2-b953-90ea826d198b"
}