{
  "abstract": "Background and Importance Monitoring antibiotic consumption is essential to rationalise their use and limit the emergence of antibiotic resistance. The AWaRe (Access, Watch, and Reserve) classification aims in particular to promote the appropriate use of these molecules. In this context, we studied the consumption of Reserve group antibiotics to describe prescribing practices and identify their determinants.Aim and Objectives The aim of this retrospective study was to describe the consumption and prescribing practices of Reserve group antibiotics during 2024. We analysed prescriptions to identify the most commonly used antibiotics, their indications, the clinical departments involved, and factors influencing their use.Material and Methods This descriptive retrospective study was conducted from January to December 2024 in a tertiary hospital in Morocco. Prescriptions for Reserve group antibiotics were analysed using departmental medication distribution sheets and corresponding medical records extracted from the hospital information system. The quantitative analysis was performed using Microsoft Excel 2025.Results A total of 187 prescriptions were analysed. Among the four families identified, polymyxins (colistin) were the most prescribed (55.6%), followed by oxazolidinones (linezolid) (21.9%). The majority of prescriptions came from the intensive care unit (64.1%). The indication was specified in 49.2% of cases, mainly for respiratory (21.9%) and urinary tract infections (8%). Combination therapy was used in 26.7% of prescriptions, mainly for synergistic purposes. An antibiogram was available for 28.8% of patients. The most frequent samples were urine (5.8%) and bronchial secretions (3.7%). The most isolated bacteria were Acinetobacter spp (12.8%), Klebsiella pneumoniae (11.2%) and Pseudomonas aeruginosa (4.8%). Total consumption was 8.1 DDD/1000 patient-days for colistin, 2.3 DDD/1000 patient-days for linezolid, and 2.8 DDD/1000 patient-days for ceftazidime-avibactam.Conclusion and Relevance The predominant use of polymyxins reflects their role against multidrug-resistant bacteria in intensive care. The high frequency of respiratory infections indicates the prevalence of nosocomial infections. Combination therapies aimed to optimise treatment despite risks. Limited availability of antibiograms led to reliance on empirical therapy, restricting targeted prescriptions. Low DDD values suggest cautious use of last-resort antibiotics. The high use of Reserve antibiotics highlights the pressure from multidrug-resistant infections in intensive care, emphasising the need for strict stewardship and enhanced clinical microbiology to slow resistance spread.Conflict of Interest No conflict of interest",
  "authors": [
    {
      "affiliations": [
        "Pharmacy- Ibn Sina Hospital- Rabat- Morocco, Hospital Pharmacy, Rabat, Morocco"
      ],
      "name": "B Yousra"
    },
    {
      "affiliations": [
        "Pharmacy- Ibn Sina Hospital- Rabat- Morocco, Laboratory of Therapeutic Chemistry- Faculty of Medicine and Pharmacy- Mohammed V University- Rabat- Morocco, Rabat, Morocco"
      ],
      "name": "M Benabbes"
    },
    {
      "affiliations": [
        "Laboratory of Galenic Pharmacy- Faculty of Medicine and Pharmacy- Tangier- Morocco., Laboratory of Galenic Pharmacy- Faculty of Medicine and Pharmacy- Tangier- Morocco., Tangier, Morocco"
      ],
      "name": "M Alami Chentoufi"
    },
    {
      "affiliations": [
        "Pharmacy- Ibn Sina Hospital- Rabat- Morocco, Hospital Pharmacy, Rabat, Morocco"
      ],
      "name": "H Aiteddouni"
    },
    {
      "affiliations": [
        "Pharmacy- Ibn Sina Hospital- Rabat- Morocco, Hospital Pharmacy, Rabat, Morocco"
      ],
      "name": "FZ Larsa"
    },
    {
      "affiliations": [
        "Pharmacy- Ibn Sina Hospital- Rabat- Morocco., Laboratory of Pharmacology and Toxicology- Faculty of Medicine and Pharmacy- Mohammed V University- Rabat- Morocco, Rabat, Morocco"
      ],
      "name": "S El Marnissi"
    },
    {
      "affiliations": [
        "Pharmacy- Ibn Sina Hospital- Rabat- Morocco, Laboratory of Galenic Pharmacy- Faculty of Medicine and Pharmacy- Rabat- Morocco, Rabat, Morocco"
      ],
      "name": "Y Alaoui"
    }
  ],
  "title": "5PSQ-085 Monitoring the consumption of reserve group antibiotics: a retrospective study",
  "uid": "96f797d9-c425-5a4d-acde-d205ee123777"
}