{
  "abstract": "Background and Importance Non-invasive neuromodulation represents an emerging therapeutic option for chronic neuropathic and post-traumatic pain, offering clinically meaningful analgesia with fewer systemic adverse effects. The Percutaneous Electrical Nerve Stimulation (PENS) BioWave System uses micro-piercing transcutaneous electrodes delivering alternating high-frequency impulses that generate an active low-frequency field capable of inhibiting pain transmission. Within the multidisciplinary pain team, the hospital pharmacist has a central role in reviewing analgesic therapy, supporting deprescribing, monitoring outcomes, and educating patients on safe medication use.Aim and Objectives The objective of this study was to evaluate the effectiveness of the BioWave PENS system over a 3-week treatment protocol regarding pain reduction, improvement of functional outcomes and activities of daily living (ADLs), patient satisfaction, and changes in analgesic consumption. A secondary objective was to describe the contribution of the hospital pharmacist in therapeutic optimisation, medication review, and follow-up.Material and Methods This open-label study was conducted from January 2024 to March 2025 in a tertiary Pain Therapy Centre (HUB). Three hundred patients with chronic pain were prescribed the non-invasive neuromodulation system and invited to participate in a structured 3-week follow-up. Collected outcomes included overall pain scores, patient satisfaction, intention to continue treatment, analgesic and opioid use, functional measures, and ADLs. The hospital pharmacist performed medication reconciliation, assessed appropriateness of analgesic therapy, monitored dosage adjustments, supported deprescribing where indicated, and documented changes in pharmacological burden and patient-reported outcomes.Results Across the treated conditions–including back pain, pre-sacral pain, post-mastectomy pain, intractable headaches, post-herpetic neuralgia, trigeminal and facial neuralgia, cervicobrachialgia, diabetic neuropathy, and shoulder pain–the BioWave system produced a mean pain reduction of 65% for back pain and 50% across all other indications. A 45% reduction in opioid and analgesic consumption was observed, supported by pharmacist-led optimisation. Quality of life and ADL improvements were reported in 82.2% of patients.Conclusion and Relevance The BioWave PENS system demonstrated meaningful clinical benefits in pain reduction, functional improvement, and reduction in medication burden. The hospital pharmacist’s involvement was essential for optimising analgesic therapy, ensuring safe deprescribing, and integrating neuromodulation into personalised pain-management pathwaysReferences and/or Acknowledgements 1. Knotkova H, et al. Neuromodulation for chronic pain-Rossi M, et al. A Novel Mini-invasive Approach to the Treatment of Neuropathic Pain: The PENS Study-Panchal, J. Pergolizzi.Conflict of Interest No conflict of interest",
  "authors": [
    {
      "affiliations": [
        "Azienda Sanitaria Locale Napoli 2 Nord, U.O.S.D. Farmacia P.O. Ospedale San Giuliano, Giugliano In Campania Na, Italy"
      ],
      "name": "D Addeo"
    },
    {
      "affiliations": [
        "Azienda Sanitaria Locale Napoli 2 Nord, U.O.S.D. Farmacia- P.O. San Giuliano, Giugliano In Campania Na, Italy"
      ],
      "name": "MR Iacolare"
    },
    {
      "affiliations": [
        "Azienda Sanitaria Locale Napoli 2 Nord, U.O.S.D. Farmacia- P.O. San Giuliano, Giugliano In Campania Na, Italy"
      ],
      "name": "I Monti"
    },
    {
      "affiliations": [
        "Azienda Sanitaria Locale Napoli 2 Nord, U.O.S.D. Farmacia- P.O. San Giuliano, Giugliano In Campania Na, Italy"
      ],
      "name": "I Filoso"
    },
    {
      "affiliations": [
        "Azienda Sanitaria Locale Napoli 2 Nord, U.O.S.D. Farmacia- P.O. San Giuliano, Giugliano In Campania Na, Italy"
      ],
      "name": "V Di Girolamo"
    },
    {
      "affiliations": [
        "Azienda Sanitaria Locale Napoli 2 Nord, U.O.S.D. Farmacia- P.O. San Giuliano, Giugliano In Campania Na, Italy"
      ],
      "name": "M De Liso"
    },
    {
      "affiliations": [
        "Azienda Sanitaria Locale Napoli 2 Nord, U.O.S.D. Hub Terapia Del Dolore, Giugliano In Campania Na, Italy"
      ],
      "name": "D Perugini"
    },
    {
      "affiliations": [
        "Azienda Sanitaria Locale Napoli 2 Nord, U.O.S.D. Hub Terapia Del Dolore, Giugliano In Campania Na, Italy"
      ],
      "name": "M Russo"
    },
    {
      "affiliations": [
        "Azienda Sanitaria Locale Napoli 2 Nord, U.O.S.D. Hub Terapia Del Dolore, Giugliano In Campania Na, Italy"
      ],
      "name": "A Vaccarella"
    },
    {
      "affiliations": [
        "Azienda Sanitaria Locale Napoli 2 Nord, U.O.S.D. Hub Terapia Del Dolore, Giugliano In Campania Na, Italy"
      ],
      "name": "P Vassetti"
    }
  ],
  "title": "4CPS-183 PENS BioWave in neuropathic and post-traumatic pain",
  "uid": "7b3c1c53-b236-50bd-8fe8-a03727483614"
}