{
  "abstract": "Background and Importance Drug incompatibility occurs when two or more drugs interact in a way that alters their physical or chemical properties, or their therapeutic effects, leading to undesirable outcomes. This can result in changes such as discoloration, precipitation, or reduced efficacy, which can compromise both the safety and effectiveness of the medications involved.Aim and Objectives To determine the frequency and types of intravenous drug incompatibilities in the ICU of a university hospital and to assess their correlation with the nursing staff’s years of experience.Material and Methods A clinical pharmacist conducted an observational study over a 3-month period in an intensive care unit to gather data on medication incompatibilities. Information on drug pairs, routes of administration, and observed incompatibilities was documented during the preparation of IV mixtures. The Stabilis 4.0 tool served as the primary reference for identifying incompatibilities, while SPSS 2.0 was utilised for statistical analysis and data processing.Results A total of 217 IV preparation and distribution procedures were observed, with 111 Y-site medication mix-ups (51%). Among these, 38 (34%) were incompatible, 21 (19%) compatible, and 52 (47%) had unknown compatibility. Of the 38 incompatibilities, nine (23.7%) involved nurses with <1 year of experience, one (2.6%) with 1–4 years, six (15.8%) with 4–5 years, and 22 (57.9%) with >6 years, suggesting increased risk at both low and high experience levels. A Student’s t-test showed a significant association between age and error frequency (t = -2.617; p = 0.009), with younger nurses more prone to errors.Conclusion and Relevance Incompatibilities can have serious clinical implications, such as altered therapeutic effects and heightened risk of adverse reactions. This study suggests that errors may resurface over time, potentially due to overconfidence and decreased vigilance, highlighting that both inexperience and excessive familiarity can contribute to incompatibility errors. These findings emphasise the need for staff to maintain focus during drug administration and underscore the importance of ongoing awareness and continuous training programmes.Conflict of Interest No conflict of interest",
  "authors": [
    {
      "affiliations": [
        "Centre Hospitalier Ibn Rochd, Pharmacy and Pharmaceutical Science, Casablanca, Morocc"
      ],
      "name": "W Ali Ahmed Abdulkareem"
    },
    {
      "affiliations": [
        "Centre Hospitalier Ibn Rochd, Pharmacy and Pharmaceutical Science, Casablanca, Morocc"
      ],
      "name": "A Bayen"
    },
    {
      "affiliations": [
        "Centre Hospitalier Ibn Rochd, Pharmacy and Pharmaceutical Science, Casablanca, Morocc"
      ],
      "name": "A Mrani Alaoui"
    }
  ],
  "title": "4CPS-004 Intravenous drug incompatibility in the ICU of a university hospital: frequency and the influence of nurses’ years of experience",
  "uid": "5bc5df87-aa63-5184-9374-fec776d3ca84"
}