{
  "abstract": "Background and Importance Antimicrobial resistance is a major public health concern, largely driven by inappropriate or prolonged use of broad-spectrum antibiotics. Antimicrobial stewardship programs (ASP) have demonstrated benefits in improving clinical outcomes and promoting rational antibiotic use. Prospective audits with regular feedback represent a key tool to encourage appropriate prescribing practices in hospital settings.Aim and Objectives To describe and assess the meetings of the ASP team conducted in a district hospital during 2024, focusing on antibiotic use, clinical cases discussed, and recommendations provided to prescribers.Material and Methods A retrospective descriptive study was conducted using the official records of the weekly meetings of the Antimicrobial Stewardship Program, held every Friday during 2024. Prescriptions registered in the hospital pharmacy program and microbiology data from the clinical history were reviewed, and the frequency of each variable was manually counted. Totals were then calculated and summarised monthly. Data included the number of meetings, antibiotics reviewed, clinical indications, and proposed interventions: reduction, continuation, duration adjustment, discontinuation, or coverage recommendations.Results A total of 35 meetings were conducted in 2024, addressing 101 cases of bacteraemia. The most frequently reviewed antibiotics were ertapenem (96), meropenem (77), and linezolid (27). The most common interventions were continuation according to clinical evolution (159), de-escalation (74), and treatment discontinuation or completion (41). Duration adjustment was recommended in 23 cases, while coverage recommendations were less frequent (6). Five deaths were recorded during follow-up. Broad-spectrum carbapenems represented a substantial proportion of discussions (173), underlining their clinical relevance and the importance of ASP supervision.Microbiological cultures with antibiograms were also analysed, highlighting the presence of extended-spectrum beta-lactamase producing E. coli (20 isolates) and Klebsiella pneumoniae (17), multidrug-resistant Pseudomonas aeruginosa (10), K. pneumoniae KPC (4), Proteus mirabilis (4), E. coli AmpC (5), and methicillin-resistant Staphylococcus aureus (7). These findings emphasise the value of microbiological surveillance and its direct impact on therapeutic decision making during the meetings.Conclusion and Relevance ASP meetings provided a structured and systematic framework to optimise antibiotic use in hospitalised patients, particularly in severe infections. The frequent interventions demonstrate the active role of the team in guiding prescription practices. These results support the continuity of multidisciplinary ASP initiatives in hospitals and align with international recommendations.Conflict of Interest No conflict of interest",
  "authors": [
    {
      "affiliations": [
        "Hospital Reina Sofia, Pharmacy Department, Tudela, Spain"
      ],
      "name": "S Erdozain"
    },
    {
      "affiliations": [
        "Hospital Reina Sofia, Pharmacy Department, Tudela, Spain"
      ],
      "name": "A Yerro Yanguas"
    },
    {
      "affiliations": [
        "Hospital Reina Sofia, Pharmacy Department, Tudela, Spain"
      ],
      "name": "D Tejada Navas"
    },
    {
      "affiliations": [
        "Hospital Reina Sofia, Pharmacy Department, Tudela, Spain"
      ],
      "name": "M Marin Marin"
    },
    {
      "affiliations": [
        "Hospital Reina Sofia, Pharmacy Department, Tudela, Spain"
      ],
      "name": "J Preciado Goldaracena"
    },
    {
      "affiliations": [
        "Hospital Reina Sofia, Pharmacy Department, Tudela, Spain"
      ],
      "name": "N Alzueta Isturiz"
    }
  ],
  "title": "4CPS-059 Analysis of antimicrobial stewardship team meetings in a district hospital: interventions and recommendations in 2024",
  "uid": "53376aef-399a-563c-9c0e-40c4aabd41a1"
}